Effect of Aerobic Training along with Garlic on Oxidative Stress Index in Obese Women with High Blood Pressure
Subject Areas : Medicinal Plants and Sports
Ghasem Torabi Palat Kaleh
1
,
Mostafa Kazemi
2
,
Ahmad Abdi
3
*
,
Asieh Abbassi Daloii
4
,
Masoomeh Alsadat Mirshafaei
5
1 - PhD Student of Sport Physiology, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2 - PhD Student of Sport Physiology, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
3 - Associate Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
4 - Associate Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
5 - Master of Sports Physiology, Department of Physical Education and Sport Science, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Keywords: Aerobic exercise, Garlic, Oxidative Stress, Hypertension, Obese Women,
Abstract :
Background: A large amount of evidence shows that oxidative stress plays a central role in hypertension pathophysiology. The aim of this study was to examine effect of aerobic training along with Garlic on oxidative stress index in obese women with high blood pressure. Materials and Methods: In this clinical trial study, 36 postmenopausal obese women with hypertension were purposefully and accessibly selected from Sari and were simple randomly divided into four groups Control (C), Aerobic Training (AT), Garlic (G) and Aerobic Training +Garlic (ATG). The training groups participated in a progressive aerobic training for eight weeks, three sessions a week (55% to 65% of the reserved heart rate and for 30 to 55 min). The groups of G and ATG were provided 1000 mg of garlic supplement for eight weeks (After breakfast and dinner). Two days before and after the protocol, blood samples were taken in fasting state. SPSS 16.0 software was used for statistical analysis. Data were analyzed using ANCOVA at p<0.05. Results: The results showed that the levels of malondialdehyde (MDA) (P=0.0001) decrease significantly in the experimental groups. Also, superoxide dismutase (SOD) (P=0.001), glutathione peroxidase (GPX) (P=0.000) and catalase (CAT) (P=0.001) in the experimental groups increased significantly compared to the C group. The amount of SOD, GPx and CAT in the ATG group was significantly higher than the AT and G group (p≤0/05). Conclusion: It seems that AT and G has interactive effects on reducing Oxidative Stress in obese women with high blood pressure.
1- Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics—2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139-e596. doi: 10.1161/CIR.0000000000000757. PMID: 31992061
2- Coylewright M, Reckelhoff JF, Ouyang P. Menopause and hypertension: an age-old debate. Hypertension. 2008;51(4):952-9. doi: 10.1161/HYPERTENSIONAHA.107.105742. PMID: 18259027.
3- Kuwabara A, Nakade M, Tamai H, Tsuboyama-Kasaoka N, Tanaka K. The association between vitamin E intake and hypertension: results from the re-analysis of the National Health and Nutrition Survey. J Nutr Sci Vitaminol. 2014;60(4):239-45. doi: 10.3177/jnsv.60.239. PMID: 25297612.
4- Rodríguez‐Mañas L, El‐Assar M, Vallejo S, López‐Dóriga P, Solís J, Petidier R, et al. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging cell. 2009;8(3):226-38. doi: 10.1111/j.1474-9726.2009.00466.x. PMID: 19245678.
5- Higashi Y, Maruhashi T, Noma K, Kihara Y. Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications. Trends Cardiovasc Med. 2014;24(4):165-9. doi: 10.1016/j.tcm.2013.12.001. PMID: 24373981.
6- Pedro-Botet J, Covas M, Martin S, Rubies-Prat J. Decreased endogenous antioxidant enzymatic status in essential hypertension. J Hum Hypertens. 2000;14(6):343-5. doi: 10.1038/sj.jhh.1001034. PMID: 10878691.
7- Xu T, Liu S, Ma T, Jia Z, Zhang Z, Wang A. Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension. Redox Biol. 2017;11:286-96. doi: 10.1016/j.redox.2016.12.019. PMID: 28030785.
8- Rowiński R, Kozakiewicz M, Kędziora-Kornatowska K, Hübner-Woźniak E, Kędziora J. Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity. Exp Gerontol. 2013;48(11):1141-6. doi: 10.1016/j.exger.2013.07.010. PMID: 23911531.
9- de Freitas Brito A, do Socorro Brasileiro-Santos M, de Oliveira CVC, da Cruz Santos A. Postexercise hypotension is volume-dependent in hypertensives: autonomic and forearm blood responses. J Strength Cond Res. 2019;33(1):234-41. doi: 10.1519/JSC.0000000000001735. PMID: 27930451.
10- Larsen MK, Matchkov VV. Hypertension and physical exercise: the role of oxidative stress. Medicina. 2016;52(1):19-27. doi: 10.1016/j.medici.2016.01.005. PMID: 26987496.
11- da Silva Almeida I, de Souza Andrade L, de Sousa AMM, Junior GC, Turri-Silva N, Cunha Nascimento Dd, et al. The Effect of Mat Pilates Training Combined With Aerobic Exercise Versus Mat Pilates Training Alone on Blood Pressure in Women With Hypertension: A Randomized Controlled Trial. Phys Ther. 2022;102(2):pzab258. doi: 10.1093/ptj/pzab258. PMID: 35084038.
12- Cornelissen VA, Smart NA. Exercise training for blood pressure: a systematic review and meta‐analysis. J Am Heart Assoc. 2013;2(1):e004473. doi: 10.1161/JAHA.112.004473. PMID: 23525435.
13- Irigoyen M-C, De Angelis K, Dos Santos F, Dartora DR, Rodrigues B, Consolim-Colombo FM. Hypertension, blood pressure variability, and target organ lesion. Curr Hypertens Rep. 2016;18(4):1-13. doi: 10.1007/s11906-016-0642-9. PMID: 27002717.
14- khatami saravi L, abdi A, barari A. Protective Effect of Aerobic Training along with Garlic on Lipocalin-2 and IL-1β in Obese Women with High Blood Pressure. Iranian J Nutr Sci Food Technol. 2020;15(1):25-34. URL: http://nsft.sbmu.ac.ir/article-1-2881-en.html
15- Ruangthai R, Phoemsapthawee J. Combined exercise training improves blood pressure and antioxidant capacity in elderly individuals with hypertension. J Exerc Sci Fit. 2019;17(2):67-76. doi: 10.1016/j.jesf.2019.03.001. PMID: 30949214. PMCID: PMC6430041.
16- Rivlin RS. Historical perspective on the use of garlic. J Nutr. 2001;131(3):951S-4S. doi: 10.1093/jn/131.3.1027S. PMID: 11238810.
17- Ried K, Travica N, Sali A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at Heart trial. Integr Blood Press Control. 2016 27;9:9-21. doi: 10.2147/IBPC.S93335. PMID: 26869811.
18- Islam F, Khadija JF, Harun-Or-Rashid M, Rahaman M, Nafady MH, Islam M, et al. Bioactive compounds and their derivatives: an insight into prospective phytotherapeutic approach against alzheimer’s disease. Oxid Med Cell Longev. 2022;11;2022:5100904. doi: 10.1155/2022/5100904. PMID: 35450410. PMCID: PMC9017558.
19- Braz NF, Carneiro MV, Oliveira-Ferreira F, Arrieiro AN, Amorim FT, Lima MM, et al. Influence of aerobic training on cardiovascular and metabolic parameters in ederly hypertensive women. Int J Prev Med. 2012;3(9):652. PMID: 23024855. PMCID: PMC3445282.
20- Ried K, Frank O, Stocks N. Aged garlic extract reduces blood pressure in hypertensives: a dose–response trial. Eur J Clin Nutr. 2013;67(1):64. doi: 10.1038/ejcn.2012.178. PMID: 23169470. PMCID: PMC3561616.
21- Campos JC, Fernandes T, Bechara LRG, Paixão NAd, Brum PC, Oliveira EMd, et al. Increased clearance of reactive aldehydes and damaged proteins in hypertension-induced compensated cardiac hypertrophy: impact of exercise training. Oxid Med Cell Longev. 2015;2015. doi: 10.1155/2015/464195. PMID: 25954323. PMCID: PMC4411445.
22- Montezano AC, Dulak-Lis M, Tsiropoulou S, Harvey A, Briones AM, Touyz RM. Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Can J Cardiol. 2015;31(5):631-41. doi: 10.1016/j.cjca.2015.02.008. PMID: 25936489.
23- Naregal GV, Devaranavadagi BB, Patil SG, Aski BS. Elevation of oxidative stress and decline in endogenous antioxidant defense in elderly individuals with hypertension. J Clin Diagn Res: JCDR. 2017;11(7):BC09. doi: 10.7860/JCDR/2017/27931.10252. PMID: 28892880. PMCID: PMC5583849.
24- Wu X, Wu H, Sun W, Wang C. Improvement of anti-Müllerian hormone and oxidative stress through regular exercise in Chinese women with polycystic ovary syndrome. Hormones. 2021;20(2):339-45. doi: 10.1007/s42000-020-00233-7. PMID: 32725588.
25- Park S-A, Lee A-Y, Park H-G, Son K-C, Kim D-S, Lee W-L. Gardening intervention as a low-to moderate-intensity physical activity for improving blood lipid profiles, blood pressure, inflammation, and oxidative stress in women over the age of 70: A pilot study. HortScience. 2017;52(1):200-5.
26- Dantas FFO, Brasileiro-Santos MdS, Batista RMF, do Nascimento LS, Castellano LRC, Ritti-Dias RM, et al. Effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and blood pressure of hypertensive elderly women: a randomized clinical trial. PloS one. 2016;11(8):e0161178. doi: 10.1371/journal.pone.0161178. PMID: 27529625. PMCID: PMC4986983.
27- Yu Y, Gao Q, Xia W, Zhang L, Hu Z, Wu X, et al. Association between physical exercise and biomarkers of oxidative stress among middle-aged and elderly community residents with essential hypertension in China. Biomed Res Int. 2018; 3;2018:4135104. doi: 10.1155/2018/4135104. PMID: 30065938. PMCID: PMC6051290.
28- Seo DY, Lee SR, Kim HK, Baek YH, Kwak YS, Ko TH, et al. Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women. Nutr Res Pract. 2012;6(3):226-31. doi: 10.4162/nrp.2012.6.3.226. PMID: 22808347. PMCID: PMC3395788.
29- Ahmadian F, Mozaffari-Khosravi H, Azaraein MH, Faraji R, Zavar-Reza J. The effect of consumption of garlic tablet on proteins oxidation biomarkers in postmenopausal osteoporotic women: A randomized clinical trial. Electron Physician. 2017;9(11):5670. doi: 10.19082/5670. PMID: 29403603. PMCID: PMC5783112.
30- Avcı A, Atlı T, Ergüder İB, Varlı M, Devrim E, Aras S, et al. Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects. Gerontology. 2008;54(3):173-6. doi: 10.1159/000130426. PMID: 18463427.
31- Shang A, Cao S-Y, Xu X-Y, Gan R-Y, Tang G-Y, Corke H, et al. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods. 2019;8(7):246. doi: 10.3390/foods8070246. PMID: 31284512. PMCID: PMC6678835.
32- Ma L, Chen S, Li S, Deng L, Li Y, Li H. Effect of allicin against ischemia/hypoxia-induced H9c2 myoblast apoptosis via eNOS/NO pathway-mediated antioxidant activity. Evid Based Complement Alternat Med. 2018;16;2018:3207973. doi: 10.1155/2018/3207973. PMID: 29849702. PMCID: PMC5926492.
33- Oboh G, Ademiluyi AO, Agunloye OM, Ademosun AO, Ogunsakin BG. Inhibitory effect of garlic, purple onion, and white onion on key enzymes linked with type 2 diabetes and hypertension. J Diet Suppl. 2019;16(1):105-18. 10.1080/19390211.2018.1438553. PMID: 29522359.
34- Atkin M, Laight D, Cummings MH. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial. J Diabetes Complications. 2016;30(4):723-7. doi: 10.1016/j.jdiacomp.2016.01.003. PMID: 26954484.
35- Ghyasi R, Moslehi A, Naderi R. Combination Effect of Voluntary Exercise and Garlic (Allium sativum) on Oxidative Stress Biomarkers and Lipid Profile in Healthy Rats. Pharmaceutical Sciences. 2019;25(3):268-73. doi: 10.15171/PS.2019.26.