The effect of aerobic exercise on JAK/STAT signaling pathway
Subject Areas : Sport Physiology
Amir Hesam Salmasi Fard
1
,
Mohammad Ali Azarbayjani
2
*
,
Farhad Riazi Rad
3
,
maghsoud peeri
4
,
Hasan Matin Homaee
5
1 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 - 1. Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
3 - Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
4 - 1. Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
5 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Keywords: aerobic exercise, JAK, STAT,
Abstract :
JAK/STAT is one of the key pathways in cell proliferation, growth, and differentiation. In most tissues, this path is known as the cause of inflammation and, in some cases, the induction and progression of diseases. In contrast, aerobic exercise regulates and modulates cell signaling by affecting signaling pathways and inflammatory and pro-inflammatory cytokines. In this article, we investigate the effect of aerobic exercise on the JAK/STAT signaling pathway.Classified articles were searched from reliable international and Iranian scientific databases. Articles were extracted from scientific databases such as Pubmed, Scopus, Science Direct, and Google Scholar. Also, articles were extracted from the scientific databases of Iran Magiran, SID, and Civilica. Out of 45 articles, 13 met this review article's criteria. Aerobic exercise affects the JAK/STAT signaling pathway in various tissues and organs. According to research results, aerobic exercise activates or inhibits this pathway differently depending on the tissue type. These effects of aerobic exercises were different in research tissues and models.Therefore, we emphasize the importance of further research on this signaling pathway and its response to exercise, especially aerobic exercise, to fully understand its effects and consequences. This research is necessary and significant in the field of exercise physiology and immunology.
1. Fu P, Zhu R, Jia J, Hu Y, Wu C, Cieszczyk P, Holmberg HC, Gong L. Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway. Nutr Metab (Lond). 2021 Jun 3;18(1):56. doi: 10.1186/s12986-021-00581-0. PMID: 34082784; PMCID: PMC8176720.
2. Arabzadeh E, Shirvani H, Ebadi Zahmatkesh M, Riyahi Malayeri S, Meftahi GH, Rostamkhani F. Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats. 3 Biotech. 2022 Sep;12(9):193. doi: 10.1007/s13205-022-03253-9. Epub 2022 Jul 26. PMID: 35910290; PMCID: PMC9325938..
3. Sun M, Zhao X, Li X, Wang C, Lin L, Wang K, Sun Y, Ye W, Li H, Zhang Y, Huang C. Aerobic Exercise Ameliorates Liver Injury in Db/Db Mice by Attenuating Oxidative Stress, Apoptosis and Inflammation Through the Nrf2 and JAK2/STAT3 Signalling Pathways. J Inflamm Res. 2023 Oct 24;16:4805-4819. doi: 10.2147/JIR.S426581. PMID: 37901382; PMCID: PMC10612520.
4. Chen L, Ru Q, Xiong Q, Yang J, Xu G, Wu Y. Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress. Oxid Med Cell Longev. 2022 Apr 18;2022:4445734. doi: 10.1155/2022/4445734. PMID: 35480870; PMCID: PMC9038420.
5. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 6;159(4):738-49. doi: 10.1016/j.cell.2014.10.029. PMID: 25417152..
6. Armstrong A, Jungbluth Rodriguez K, Sabag A, Mavros Y, Parker HM, Keating SE, Johnson NA. Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta-analysis. Obes Rev. 2022 Aug;23(8):e13446. doi: 10.1111/obr.13446. Epub 2022 Apr 5. PMID: 35383401; PMCID: PMC9540641.
7. Calcaterra V, Vandoni M, Rossi V, Berardo C, Grazi R, Cordaro E, Tranfaglia V, Carnevale Pellino V, Cereda C, Zuccotti G. Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity. Int J Environ Res Public Health. 2022 Jun 5;19(11):6908. doi: 10.3390/ijerph19116908. PMID: 35682490; PMCID: PMC9180584.
8. Kim MK, Kim Y, Park S, Kim E, Kim Y, Kim Y, Kim JH. Effects of Steady Low-Intensity Exercise on High-Fat Diet Stimulated Breast Cancer Progression Via the Alteration of Macrophage Polarization. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420949678. doi: 10.1177/1534735420949678. PMID: 32909498; PMCID: PMC7493231.
9. Padrão AI, Figueira AC, Faustino-Rocha AI, Gama A, Loureiro MM, Neuparth MJ, Moreira-Gonçalves D, Vitorino R, Amado F, Santos LL, Oliveira PA, Duarte JA, Ferreira R. Long-term exercise training prevents mammary tumorigenesis-induced muscle wasting in rats through the regulation of TWEAK signalling. Acta Physiol (Oxf). 2017 Apr;219(4):803-813. doi: 10.1111/apha.12721. Epub 2016 Jun 27. PMID: 27228549.
10. Hajinajaf, S., Shirvani, H., Roozbehani, M., Khademi, A. The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor. Jundishapur Scientific Medical Journal, 2022; 21(3): 408-421. doi: 10.32598/JSMJ.21.3.2793.
11. Borjian Fard M, Choobineh S, Soori R, Mazaheri Z. Investigating role of the JAK/STAT pathway in cardiac hypertrophy induced by the interval and continuous trainings in adult male rats. mjms 2019; 22 (4) :173-180.
12. Babaei P, Hoseini R. Exercise training modulates adipokine dysregulations in metabolic syndrome. Sports Med Health Sci. 2022 Jan 20;4(1):18-28. doi: 10.1016/j.smhs.2022.01.001. PMID: 35782776; PMCID: PMC9219261.
13. Liu J, Shen Q, Wu Y. Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway. Life Sci. 2008 May 7;82(19-20):991-6. doi: 10.1016/j.lfs.2008.02.012. Epub 2008 Mar 2. PMID: 18400235.
14. Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022 Jan 11;55(1):31-55. doi: 10.1016/j.immuni.2021.12.013. PMID: 35021057; PMCID: PMC8773457.
15. Liu ZK, Li C, Zhang RY, Wei D, Shang YK, Yong YL, Kong LM, Zheng NS, Liu K, Lu M, Liu M, Hu CX, Yang XZ, Chen ZN, Bian H. EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling. Mol Cancer. 2021 May 27;20(1):79. doi: 10.1186/s12943-021-01377-9. PMID: 34044846; PMCID: PMC8157759.
16. Casanova JL, Holland SM, Notarangelo LD. Inborn errors of human JAKs and STATs. Immunity. 2012;36(4):515-28.
17. Chen B, Ning K, Sun ML, Zhang XA. Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review. Cell Commun Signal. 2023 Apr 3;21(1):67. doi: 10.1186/s12964-023-01094-4. PMID: 37013568; PMCID: PMC10071628.
18. Attia YM, Tawfiq RA, Gibriel AA, et al. Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model. Biochemical Pharmacology. 2021 Apr;186:114497. DOI: 10.1016/j.bcp.2021.114497. PMID: 33675775.
19. Stevens LE, Peluffo G, Qiu X, Temko D, Fassl A, Li Z, Trinh A, Seehawer M, Jovanović B, Alečković M, Wilde CM, Geck RC, Shu S, Kingston NL, Harper NW, Almendro V, Pyke AL, Egri SB, Papanastasiou M, Clement K, Zhou N, Walker S, Salas J, Park SY, Frank DA, Meissner A, Jaffe JD, Sicinski P, Toker A, Michor F, Long HW, Overmoyer BA, Polyak K. JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States. Cancer Res. 2023 Jan 18;83(2):264-284. doi: 10.1158/0008-5472.CAN-22-0423. PMID: 36409824; PMCID: PMC9845989.
20. Yao B, Li L, Guan X, Zhu J, Liu Q, Qu B, Ding H. Endurance Training Inhibits the JAK2/STAT3 Pathway to Alleviate Sarcopenia. Physiol Res. 2024 Apr 30;73(2):295-304. doi: 10.33549/physiolres.935234. PMID: 38710060; PMCID: PMC11081189.
21. Li M, Mo J, Wu D, He H, Hu P. Treadmill training improves neural function recovery in rats with spinal cord injury via JAK2/STAT3 signaling pathway and attenuating apoptosis. Neuroreport. 2024 Sep 4;35(13):811-821. doi: 10.1097/WNR.0000000000002062. Epub 2024 Jul 8. PMID: 38973489.
22. Shan Y, Wang L, Sun J, Chang S, Di W, Lv H. Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway. Brain Behav. 2023 Jun;13(6):e3030. doi: 10.1002/brb3.3030. Epub 2023 May 4. PMID: 37143406; PMCID: PMC10275560.
23. Zhao J, Feng Y, Rao Z, Li H, Xu J, Cui S, Lai L. Exercise combined with heat treatment improves insulin resistance in diet-induced obese rats. J Therm Biol. 2023 Aug;116:103651. doi: 10.1016/j.jtherbio.2023.103651. Epub 2023 Jul 10. PMID: 37459707.
24. Lei Y, He J, Hu F, Zhu H, Gu J, Tang L, Luo M. Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway. BMC Pulm Med. 2023 Oct 12;23(1):385. doi: 10.1186/s12890-023-02656-5. PMID: 37828534; PMCID: PMC10568888.
25. Chen Y, Zhang S, Ye L, Chen H, Yu L, Wu D. An Acute Bout of Exercise Suppresses Appetite via Central Lactate Metabolism. Neuroscience. 2023 Feb 1;510:49-59. doi: 10.1016/j.neuroscience.2022.11.013. Epub 2022 Dec 15. PMID: 36529295.
26. Lin L, Wang Y, Xu W, Huang C, Hu J, Chen X, Lv X, Qin Y, Zhao X, Li H. Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice. Dis Markers. 2022 May 5;2022:6010504. doi: 10.1155/2022/6010504. PMID: 35578689; PMCID: PMC9107038.
27. Odermatt TS, Dedual MA, Borsigova M, Wueest S, Konrad D. Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction. Int J Obes (Lond). 2020 Mar;44(3):707-714. doi: 10.1038/s41366-019-0444-7. Epub 2019 Aug 29. PMID: 31467419.
28. Almeida-Oliveira AR, Aquino-Junior J, Abbasi A, Santos-Dias A, Oliveira-Junior MC, Alberca-Custodio RW, Rigonato-Oliveira NC, Salles-Dias LP, Damaceno-Rodrigues NR, Caldini EG, Arantes-Costa FM, Ligeiro-Oliveira AP, Belvisi MG, Vieira RP. Effects of aerobic exercise on molecular aspects of asthma: involvement of SOCS-JAK-STAT. Exerc Immunol Rev. 2019;25:50-62. PMID: 30785869.
29. Hosseini Askarabadi S, Mirnasori R, Rahmati M. Effect of 6 weeks aerobic training on peripheral neuropathic pain and expression of NOTCH1 pathway genes in posterior spinal cord of diabetic male rats. JSSU 2019; 27 (2) :1238-1253.