The effect of L-arginine supplementation along with 6 weeks of Aquatic training on changes in blood pressure and fasting blood sugar in older peoples with Hypertension
Subject Areas : Sport Physiology
Yaser Kazemzadeh
1
,
Pegah Hooshangi
2
*
,
Yasamin Soltani
3
1 - Assistant Professor, Graduated from Kharazmi University, Tehran, Iran.
2 - Exercise Physiology Department, East Tehran Branch, Islamic Azad University, Tehran, Iran.
3 - PhD student in sports physiology, Sports Physiology Department, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran.
Keywords: L-arginine, insulin resistance, hypertension, aquatic training,
Abstract :
Background and purpose: The factors that control blood pressure, the most important of which are inactivity and improper nutrition. The present study was conducted with the aim of investigating the effect of arginine supplementation on blood pressure and glucose metabolism in elderly people with mild Hypertension. Materials and methods: 43 elderly men and women in the age range of 55 to 70 years with mild hypertension were selected as participants and were randomly divided into 4 groups, including the aquatic training group (AT), L-arginine supplementation (ARG), aquatic training + L-arginine supplementation (AT+ARG) and control (CON). AT group did sports training in water for 6 weeks. ARG group received 100 mg of L-arginine per body weight and AT+ ARG group received L-arginine supplement during 6 weeks of water sports training. The control group also received only placebo. The values measured in the present study included aerobic power, systolic blood pressure, diastolic blood pressure and fasting blood glucose. The findings were compared using one-way analysis of variance and Tukey's post hoc test at a significance level of ≥0.05. Results: The findings of the present study showed that the diastolic blood pressure of the subjects did not differ significantly (P=0.239), but the difference between the systolic blood pressure of the group was significant (P=0.031). Also, the change of fasting blood glucose of the samples in the 4 groups shows a significant difference (P=0.011). L-arginine consumption group and sports training + L-arginine consumption group showed a significant difference with the control group (P=0.0001 and P=0.001, respectively). Conclusion: The results of the present study showed that consuming L-arginine for 6 weeks in the elderly with hypertension can lead to improvement of their systolic blood pressure and fasting blood sugar, but adding training cannot double its effect. slow All sports training have proven effects in modulating blood pressure and lowering blood sugar in people who have used it for some time, but it seems that observing the double effect of activities on these indicators requires long training programs, which future studies show. It will clarify more.
1. Mirftahi Maryam, Saedi Soumae Olya Ahmed, Sotoudeh Giti, Mohajeri Tehrani Mohammad Reza, Keshavarz Seyed Ali, Hosseini Mostafa, Seifi Rad Soroush. Investigating the effect of L-arginine supplementation on blood pressure in overweight people with pre-diabetes. Iranian Journal of Diabetes and Lipid, Bimonthly, April-May 2013, Volume 11 (Number 4) 393-399. 2. Asadi Sara, Mozafari Khosravi Hassan, Rahimi
2. Mahnaz, Naghizadeh Mohammad Mehdi. The effect of L-arginine supplementation on the lipid profile of patients with type 2 diabetes. Journal of Fasa University of Medical Sciences, fourth year, number 1, spring 2013.
3. Jennings, A.; MacGregor, A.; Pallister, T.; Spector, T.; Cassidy, A. Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: A twin study. Int. J. Cardiol. 2016, 223, 992–998
4. Pahlavani N, Salehi Abarghouei A, Karimian J, Rouhani MH, Entezari MH. The Effect of Supplementation of L - Arginine on the Lipid Profile, Fasting Blood Sugar and Blood Pressure in Healthy Subjects with thepreventive Approach of Cardiovascular Diseases. J RafsanjanUniv Med Sci 2015; 14(6): 493-506. [Farsi]
5. Bahrami Davood, Mozaffari-Khosravi H. The Effect of Oral L-arginine Supplementation on Blood Pressure in Patients with Metabolic Syndrome: A Randomized Clinical Trial. IRANIAN JOURNAL OF DIABETES AND OBESITY, VOLUME 10, NUMBER 1, SPRING 2018.
6. Vianna L C., Fernandes I A., Barbosa T C., Amaral T G., Rocha N G., Secher N H. and Nóbrega A C.. Absent increase in vertebral artery blood flow during L-arginine infusion in hypertensive men. Am J Physiol Regul Integr Comp Physiol 315: R820–R824, 2018.
7. Stamler J, Caggiula A, Grandits GA, Kjelsberg M, Cutler JA. Relationship to blood pressure of combinations of dietary macronutrients. Findings of the Multiple Risk Factor Intervention Trial (MRFIT). Circulation 1996;94:2417-23.
8. Vasdev S, Gill V. Effect of soybean in diet on blood pressure. Hypertens Canada 2006;88:3-5.
9. Campese VM, Amar M, Anjali C, Medhat T, Wurgaft A. Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension. J Hum Hypertens 1997;11:527-32.
10. Mann GE, Yudilevich DL, Sobrevia L. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 2003;83:183-252.
11. Eid HM, Reims H, Arnesen H, Kjeldsen SE, Lyberg T, Seljeflot I. Decreased levels of asymmetric dimethylarginine during acute hyperinsulinemia. Metabolism 2007;56:464-9.
12. Barrera R S, Romerob F G, Lucas Ferreira G, Barbosa T d C, Nunes M T. Exercise training reverses the negative effects of chronic L-arginine supplementation on insulin sensitivity. Life Sciences 191 (2017) 17–23.
13. Boon M R. and et al. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study. Diabetologia (2019) 62:112–122.
14. Lucotti P and et al. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 291: E906–E912, 2006.
15. Hu S, Han M, Rezaei A, Li D, Wu G, Ma X. L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes. Curr Protein Pept Sci. 2017;18(6):599-608. doi: 10.2174/1389203717666160627074017. PMID: 27356939.
16. Poggiogalle E, Fontana M, Giusti AM, Pinto A, Iannucci G, Lenzi A, Donini LM. Amino Acids and Hypertension in Adults. Nutrients. 2019 Jun 27;11(7):1459. doi: 10.3390/nu11071459. PMID: 31252583; PMCID: PMC6683075.
17. Vasdev S, Gill V. The antihypertensive effect of arginine. Int J Angiol. 2008 Spring;17(1):7-22. doi: 10.1055/s-0031-1278274. PMID: 22477366; PMCID: PMC2728371.
18. Kass, L., Weekes, J. & Carpenter, L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr 66, 411–418 (2012). https://doi.org/10.1038/ejcn.2012.4.
19. Khamseh ME, Sepanlou SG, Hashemi-Madani N, Joukar F, Mehrparvar AH, Faramarzi E, Okati-Aliabad H, Rahimi Z, Rezaianzadeh A, Homayounfar R, Moradpour F, Valizadeh N, Kheirandish M, Zaboli E, Moslem A, Ahmadi A, Hamzeh B, Harooni J, Pourfarzi F, Abolghasemi MR, Safarpour AR, Aminisani N, Mohammadi Z, Eghtesad S, Poustchi H, Malekzadeh R. Nationwide Prevalence of Diabetes and Prediabetes and Associated Risk Factors Among Iranian Adults: Analysis of Data from PERSIAN Cohort Study. Diabetes Ther. 2021 Nov;12(11):2921-2938. doi: 10.1007/s13300-021-01152-5. Epub 2021 Sep 30. PMID: 34595726; PMCID: PMC8521563.
20. Stamler J, Brown IJ, Daviglus ML, Chan Q, Kesteloot H, Ueshima H, Zhao L, Elliott P; INTERMAP Research Group. Glutamic acid, the main dietary amino acid, and blood pressure: the INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure). Circulation. 2009 Jul 21;120(3):221-8. doi: 10.1161/CIRCULATIONAHA.108.839241. Epub 2009 Jul 6. PMID: 19581495; PMCID: PMC4048930.
21. Zhang L, Li F, Guo Q, Duan Y, Wang W, Zhong Y, Yang Y, Yin Y. Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis. Nutrients. 2020 May 2;12(5):1299. doi: 10.3390/nu12051299. PMID: 32370170; PMCID: PMC7282259.
22. Carpio-Rivera E, Moncada-Jiménez J, Salazar-Rojas W, Solera-Herrera A. Acute Effects of Exercise on Blood Pressure: A Meta-Analytic Investigation. Arq Bras Cardiol. 2016 May;106(5):422-33. doi: 10.5935/abc.20160064. Epub 2016 May 6. PMID: 27168471; PMCID: PMC4914008.
23. Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA, Williamson JD, Wright JT2017ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [published online ahead of print November 13, 2017].Hypertension. doi: 10.1161/HYP.0000000000000065.
24. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA; American College of Sports Medicine. American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004 Mar;36(3):533-53. doi: 10.1249/01.mss.0000115224.88514.3a. PMID: 15076798.