Comparing the effect of antioxidant and coenzyme 10Q supplementation on some indicators of muscle injury in water polo boys
Subject Areas : Sport Physiology
Peyman Azarmidakhtian
1
(Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran)
Alireza Eizadi
2
(Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran)
Mohammad Samadi
3
(Department of Exercise Physiology, Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran)
Keywords: Antioxidant supplement, Coenzyme Q10, CK, LDH, AST,
Abstract :
Background: Reactive oxygen species are produced in response to strenuous, prolonged exercise, such as swimming, which results in cell damage. The aim of this study was to compare the effect of antioxidant and coenzyme 10Q supplementation on some indicators of muscle injury in water polo boys. Materials and Methods: The 24 boy water polo players with at least 5 years of training experience and in the age range of 17 to 23 years were randomly divided into three groups )8 people (of vitamin C, coenzyme Q10 and control. Subjects in the vitamin C group (500 mg of vitamin C tablets) and subjects in the coenzyme Q10 group (300 mg of coenzyme Q10 tablets) were consumed daily with food for two weeks. Trainings were performed for two weeks, 6 sessions per week and 90 minutes per session. Evaluation of CK, LDH and AST indices in the state of at least twelve hours of fasting was performed in three stages: previous, immediately and 24 hours after the completion of the protocol. One-factor analysis of variance test with repeated measures was used. Results: The results showed that CPK decreased significantly after fourteen days of supplementation in coenzyme Q10 group and increased significantly 24 hours after the last training session and in vitamin C group after fourteen days of supplementation and 24 hours after the last training session increased significantly. There was no significant difference in LDH and AST levels between the groups (P <0.05). Conclusion: It seems taking coenzyme Q10 supplements may possibly reduce some indicators of muscle damage after water polo training.
1. Rod E, Ivkovic A, Boric I, Jankovic S, Radic A, Hudetz D. Acute hyperextension/valgus trauma to the elbow in top-level adult male water polo goalkeepers: a cause of osteochondritis disecans of the capitellum? Injury. 2013 Sep;44 Suppl 3:S46-8. doi: 10.1016/S0020-1383(13)70197-9. PMID: 24060018.
2. Di Renzo L, Galvano F, Orlandi C, Bianchi A, Di Giacomo C, La Fauci L, et al. Oxidative stress in normal- weight obese syndrome. Obesity 2012;18(11):21-30.
3. Akil M. Effect of acute exercises applied to sedentaries on various enzyme levels related tomuscle damages. Afr J Microbiol Res 2012;6(2):284-7.
4. Vimercatti B , ZovicoB, Carvalho B, Barreto B, Machado A. Two doses of caffeine do not increase the risk of exercise-induced muscle damage or leukocytosis. Phys Edu Sport 2008;19(1):52-1.
5. Brancaccio P, Maffulli N, Limongelli FM. Creatine kinase monitoring in sport medicine. Br Med Bull. 2007;81-82:209-30. doi: 10.1093/bmb/ldm014. Epub 2007 Jun 14. PMID: 17569697.
6. Shenkman BS, Litvinova KS , Gasnikova NM, Tarakin PP, Chistiakov IN, et al. Creatine as a metablic controller of skeletal muscles structure and function in strength exercise in humans. The cellular 2011;35(4):452-62.
7. Nozari V, Zare A. Response of Some of the Muscle Damage Enzymes to an Acute Exercise Session Following Adaption to 8 Weeks Plyometric Training with Overload among Young Female Handball Player. psj. 2020; 18 (4) :17-23
URL: http://psj.umsha.ac.ir/article-1-587-en.html.
8. Sharifian M, Behpoor N, Mohajerani H R, Darabi F. Effects Alliume Satium and Silybum Marianum Supplements with four Weeks Incremental Training on Some Serum Indicators of Serum Muscle and Liver Damage in Wrestlers. aumj. 2020; 9 (2) :154-164
URL: http://aums.abzums.ac.ir/article-1-1085-en.html
9. Stajer V, Vranes M, Ostojic SM. Correlation between biomarkers of creatine metabolism and serum indicators of peripheral muscle fatigue during exhaustive exercise in active men. Res Sports Med. 2020 Jan-Mar;28(1):147-154. doi: 10.1080/15438627.2018.1502185. Epub 2018 Jul 20. PMID: 30028191.
10. Ochoa JJ, Quiles JL, López-Frías M, Huertas JR, Mataix J. Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet. J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1211-8. doi: 10.1093/gerona/62.11.1211. PMID: 18000140.
11. Raygan F, Rezavandi Z, Dadkhah Tehrani S, Farrokhian A, Asemi Z. The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. Eur J Nutr. 2016 Dec;55(8):2357-2364. doi: 10.1007/s00394-015-1042-7. Epub 2015 Sep 18. PMID: 26385228.
12. Khanvari T, Sardari F, Rezaei B. The Effect of 14 Days of Coenzyme Q10 Supplementation on Muscle Damage and Fatigue Indices Following a Bout Exhausting Exercise Activity in Passive Men. J Arak Uni Med Sci. 2020; 23 (3) :386-397
URL: http://jams.arakmu.ac.ir/article-1-3653-en.html.
13. Emami A, Tofighi A, Asri S. The Effect of 6 Weeks of Endurance Training on Gene Expression of GSK-3β in the Motor Area of the Spinal Cord of Male Wistar Rats with Diabetic Neuropathy. J of Sport Biosciences 2017;9(3):351-69. [Farsi].
14. Changizi M, Ebrahimi M, Avandi M. Acute effects of coenzyme Q10 supplement on serum parameters of oxidative stress following one session of resistance training in male college athletes. Koomesh 2015;16(4):603-10. [Farsi].
15. Kizaki K, Terada T, Arikawa H, Tajima T, Imai H, Takahashi T, Era S. Effect of reduced coenzyme Q10 (ubiquinol) supplementation on blood pressure and muscle damage during kendo training camp: a double-blind, randomized controlled study. J Sports Med Phys Fitness. 2015 Jul-Aug;55(7-8):797-804. Epub 2014 Nov 4. PMID: 25369277.
16. Taghiyar M, Darvishi L, Askari G, Feizi A, Hariri M, Mashhadi NS, Ghiasvand R. The effect of vitamin C and e supplementation on muscle damage and oxidative stress in female athletes: a clinical trial. Int J Prev Med. 2013 Apr;4(Suppl 1):S16-23. PMID: 23717764; PMCID: PMC3665020.
17. Azizi M, Razmjou S, Rajabi H, Hedayati M, Sharifi S. Effects of antioxidant supplementation on oxidative stress and muscle injury in elite female swimmers after a strenuous training period. Iranian J Nutr Sci Food Technol. 2010; 5 (3) :1-10
URL: http://nsft.sbmu.ac.ir/article-1-359-fa.html.
18. Rabienejad A, Joshagani HR, Farzaneh Hesari A, Agaalinejad H, Khoshdel M. Effect of vitamin C and E supplementation on lipid peroxidation and delayed onset muscle soreness in professional basketball players. J Gorgan Univ Med Sci. 2014; 16 (2) :12-20
URL: http://goums.ac.ir/journal/article-1-2043-en.html.
19. Castellano J, Casamichana D. Heart Rate and Motion Analysis by GPS in Beach Soccer. J Sports Sci Med. 2010 Mar 1;9(1):98-103. PMID: 24149392; PMCID: PMC3737961.
20. Modi K, Santani DD, Goyal RK, Bhatt PA. Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats. Biol Trace Elem Res. 2006 Jan;109(1):25-34. doi: 10.1385/BTER:109:1:025. PMID: 16388100.
21. Nejatmand N, Ramezani A, Barati A H. Effect of Consumption short-term CoQ10 supplementation on markers of delayed onset muscle soreness. RJMS. 2014; 21 (119) :77-85
URL: http://rjms.iums.ac.ir/article-1-3105-en.html.
22. Leelarungrayub D, Sawattikanon SN, Klaphajone J, Pothongsunan P, Bloomer RJ. Coenzyme Q10 supplementation decreases oxidative stress and improves physical performance in young swimmers: A pilot study. The Open Sports Medicine Journal 2010;4(1):1-8.
23. Porter DA, Costill DL, Zachwieja JJ, Krzeminski K, Fink WJ, Wagner E, Folkers K. The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men. Int J Sports Med. 1995 Oct;16(7):421-7. doi: 10.1055/s-2007-973031. PMID: 8550248.
24. Demirci, Nevzat and Ebru Beytut. “Effects of Oral Coenzyme Q10 on Preventing the Accumulation of Lactic Acid Developing during the Exercise Performances of Endurance Skiing Athletes.” American Journal of Sports Science and Medicine 2 (2014): 65.
25. Tezam M. The effect of taking a multivitamin supplement on delayed muscle contusion after a session of resistance training in trained men Master Thesis, Sports Physiology, Faculty of Physical Education and Sports Sciences, Shahid Chamran University of Ahvaz 2017. [Farsi].
26. Ostman B, Sjödin A, Michaëlsson K, Byberg L. Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans. Nutrition. 2012 Apr;28(4):403-17. doi: 10.1016/j.nut.2011.07.010. Epub 2011 Nov 12. PMID: 22079391.
27. Tian G, Sawashita J, Kubo H, Nishio SY, Hashimoto S, Suzuki N, Yoshimura H, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S, Higuchi K. Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal. 2014 Jun 1;20(16):2606-20. doi: 10.1089/ars.2013.5406. Epub 2013 Dec 14. PMID: 24124769; PMCID: PMC4025630.