High Intensity Interval Training on Adiponectin And ALT, AST, ALP Enzymes In obese And Overweight Boys
Subject Areas : Sport Physiology
Elhamalsadat Zeinali
1
(Master of Exercise Physiology, Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran. )
Saeed Ganjizadeh Tari
2
(Master of Exercise Physiology, Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran. )
Masoumeh Hehalizadeh
3
(Department of Exercise Physiology, Sport Medicine Research Center, Sport Sciences Research Institute, Tehran, Iran.)
Keywords: Adiponectin, ALT, AST, ALP, HIIT, Overweight,
Abstract :
Background: This study was conducted to evaluate the effect of eight weeks of High-Intensity Interval Training (HIIT) on adiponectin and AST, ALT, and ALP enzymes in obese and overweight boys. Materials and Methods: Subjects were 22 boys aged 12-14 years old, who were randomly assigned to experimental and control groups. Experimental group: mean weight 80.08 ± 16.08, Vo2max was 36.56 ± 2.49, and BMI was 30.27 ± 5.9 and control group: mean weight 67.91 ± 7.95, and Vo2max was 44.4 ± 2.75, 38 and BMI of 60.26 ± 6.3. The experimental group performed eight weeks of HIIT training with 80% HRR intensity at 10 turns of 60 seconds, with 60 seconds rest on exercise bikes for 3 days a week. Blood samples were taken 24 and 48 hours before and after the training, ANCOVA was used for data analysis using SPSS 21 software at a significant level (p <0.05). Results: The results showed that HIIT reduced the levels of Adiponectin and AST and ALP enzymes, but this was not significant (P≥0.05). This exercise also reduced ALT and fat percentage and increased Vo2max in subjects, with changes in all three variables significant (P≤0 / 05). Conclusion: It seems HIIT can reduce the percentage of fat and ALT enzyme in children, which can help prevent many metabolic diseases. Also, HIIT can play a role in liver health in overweight and obese children.
1. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet. 2002 Aug 10;360(9331):473-82. DOI: 10.1016/S0140-6736(02)09678-2. PMID: 12241736.
2. Amiri. P., Ghofranipour. F., Ahmadi. F., Hooman. H., Hosseinpanah. F. & Jalali-Farahani. S. Personal barriers to lifestyle modification in overweight/obese adolescents: a qualitative study. Iranian Journal of Endocrinology and Metabolism. 2009;11(5):521-601. URL: http://ijem.sbmu.ac.ir/article-1-897-en.html
3. Naylor PJ, McKay HA. Prevention in the first place: schools a setting for action on physical inactivity. Br J Sports Med. 2009 Jan;43(1):10-3. DOI: 10.1136/bjsm.2008.053447. Epub 2008 Oct 29. PMID: 18971250.
4. Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease. Int J Mol Sci. 2014 Apr 11;15(4):6184-223. DOI: 10.3390/ijms15046184. PMID: 24733068; PMCID: PMC4013623.
5. Cercato C, Fonseca FA. Cardiovascular risk and obesity. Diabetol Metab Syndr. 2019 Aug 28;11:74. doi: 10.1186/s13098-019-0468-0. PMID: 31467596; PMCID: PMC6712750.
6. Richard AJ, White U, Elks CM, et al. Adipose Tissue: Physiology to Metabolic Dysfunction. [Updated 2020 Apr 4]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000- https://www.ncbi.nlm.nih.gov/books/NBK555602
7. Parimisetty A, Dorsemans AC, Awada R, Ravanan P, Dietel N, Lefebvre d'Hellencourt C. Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research. J Neuroinflammation. 2016 Mar 24;13(1):67. DOI: 10.1186/s12974-016-0530-x. PMID: 27012931; PMCID: PMC4806498.
8. Esfahani M, Movahedian A, Bianchi M, Goodarzi MT. Adiponectin: an adipokine with protective features against metabolic syndrome. Iran J Basic Med Sci. 2015 May;18(5):430-42. PMID: 26124928; PMCID: PMC4475650.
9. Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C, Bianco A, Daniele A. New insight into adiponectin's role in obesity and obesity-related diseases. Biomed Res Int. 2014; 2014:658913. DOI: 10.1155/2014/658913. Epub 2014 Jul 7. PMID: 25110685; PMCID: PMC4109424.
10. Riyahi Malayeri S, Azadniya A, Rasaee M J. Effect of Eight-week high-intensity interval training and resveratrol intake on serum adiponectin and resistin in type 2 diabetic rats. idle. 2019; 18 (1) :8-1 URL: http://ijdld.tums.ac.ir/article-1-5708-en.html
11. Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shuichi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 2007 Jul;6(1):55-68. DOI: 10.1016/j.cmet.2007.06.003. PMID: 17618856.
12. You T, Nicklas BJ. Effects of exercise on adipokines and the metabolic syndrome. Curr Diab Rep. 2008 Feb;8(1):7-11. DOI: 10.1007/s11892-008-0003-4. PMID: 18366992.
13. Parastesh M, Saremi A, Ebadianejad M. Effect of Chromium Picolinate Supplementation Combined With Resistance Training on Liver Enzymes Levels and Insulin Resistance in Patients With Type 2 Diabetes. Caja. 2019; 9 (3) :3792-3803 URL: http://cmja.arakmu.ac.ir/article-1-666-en.html.
14. Davoodi M, Moosavi H, Nikbakht M. The effect of eight weeks selected aerobic exercise on liver parenchyma and liver enzymes (AST, ALT) of fatty liver patients. J Shahrekord Univ Med Sci. 2012; 14 (1) :84-90. URL: http://78.39.35.44/article-1-1054-en.html.
15. Hall P, Cash J. What is the real function of the liver 'function' tests? Ulster Med J. 2012 Jan;81(1):30-6. PMID: 23536736; PMCID: PMC3609680.
16. Kondo T, Kobayashi I, Murakami M. Effect of exercise on circulating adipokine levels in obese young women. Endocr J. 2006 Apr;53(2):189-95. DOI: 10.1507/endocrj.53.189. PMID: 16618976.
17. Golbidi S, Laher I. Exercise-induced adipokine changes and the metabolic syndrome. J Diabetes Res. 2014;2014:726861. DOI: 10.1155/2014/726861. Epub 2014 Jan 19. PMID: 24563869; PMCID: PMC3915640.
18. Polito R, Monda V, Nigro E, Messina A, Di Maio G, Giuliano MT, Orrù S, Imperlini E, Calcagno G, Mosca L, Mollica MP, Trinchese G, Scarinci A, Sessa F, Salerno M, Marsala G, Buono P, Mancini A, Monda M, Daniele A, Messina G. The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity. Front Physiol. 2020 Apr 22; 11:356. doi: 10.3389/fphys.2020.00356. PMID: 32390865; PMCID: PMC7188914.
19. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011; 2011:868305. DOI: 10.1155/2011/868305. Epub 2010 Nov 24. PMID: 21113312; PMCID: PMC2991639.
20. Ito S. High-intensity interval training for health benefits and care of cardiac diseases - The key to an efficient exercise protocol. World J Cardiol. 2019 Jul 26;11(7):171-188. DOI: 10.4330/ wjc.v11.i7.171. PMID: 31565193; PMCID: PMC6763680.
21. Kordi M, Choopani S, Hemmatinafar M, Choopani Z. The effects of six weeks high-intensity interval training (HIIT) on resting plasma levels of adiponectin and fat loss in sedentary young women. jmj. 2013; 11 (1) :23-31
URL: http://jmj.jums.ac.ir/article-1-35-en.html
22. Avazpor, S., Fazel Kalkhoran, J., & Amini, H. A. Effect of 8 Weeks of High-Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses. Novelty in Biomedicine, 2016, 4(3), 87-92. https://doi.org/10.22037/nbm.v4i3.10474
23. Racil G, Ben Ounis O, Hammouda O, Kallel A, Zouhal H, Chamari K, Amri M. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol. 2013 Oct;113(10):2531-40. DOI: 10.1007/s00421-013-2689-5. Epub 2013 Jul 4. PMID: 23824463.
24. Gerosa-Neto J, Antunes BM, Campos EZ, Rodrigues J, Ferrari GD, Rosa Neto JC, Bueno CR Junior, Lira FS. Impact of long-term high-intensity interval and moderate-intensity continuous training on subclinical inflammation in overweight/obese adults. J Exerc Rehabil. 2016 Dec 31;12(6):575-580. DOI: 10.12965/jer.1632770.385. PMID: 28119880; PMCID: PMC5227320.
25. Ryan AS, Nicklas BJ, Berman DM, Elahi D. Adiponectin levels do not change with moderate dietary-induced weight loss and exercise in obese postmenopausal women. Int J Obes Relat Metab Disord. 2003 Sep;27(9):1066-71. DOI: 10.1038/SJ.ijo.0802387. PMID: 12917712.
26. Shamsoddini A, Sobhani V, Ghamar Chehreh ME, Alavian SM, Zaree A. Effect of Aerobic and Resistance Exercise Training on Liver Enzymes and Hepatic Fat in Iranian Men With Nonalcoholic Fatty Liver Disease. Hepat Mon. 2015 Oct 10;15(10):e31434. DOI: 10.5812/hepatmon.31434. PMID: 26587039; PMCID: PMC4644631.
27. Barani F, Afzalpour M E, Ilbiegi S, Kazemi T, Mohammadi Fard M. The effect of resistance and combined exercise on serum levels of liver enzymes and fitness indicators in women with nonalcoholic fatty liver disease. J Birjand Univ Med Sci. 2014; 21 (2) :188-202URL: http://journal.bums.ac.ir/article-1-1588-en.html
28. Khoshbaten M, Fatahi E, Soomi H, Tarzmani M, Farhang S, et al. Clinico- biochemical comparison of patients with Nonalcoholic fatty liver disease and healthy populace, Zahedan J Res Med Sci. 2009; 11(1): e94431. https://sites.kowsarpub.com/zjrms/articles/94431.
29. Omagari K, Kadokawa Y, Masuda J, Egawa I, Sawa T, Hazama H, Ohba K, Isomoto H, Mizuta Y, Hayashida K, Murase K, Kadota T, Murata I, Kohno S. Fatty liver in non-alcoholic non-overweight Japanese adults: incidence and clinical characteristics. J Gastroenterol Hepatol. 2002 Oct;17(10):1098-105. DOI: 10.1046/j.1440-1746.2002.02846. x. PMID: 12201871.