مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-303851820261251 Investigating the Effect of 12-Week Swim Training and Vitamin C Supplementation on TGF-β Expression in Lung Tissue of Mice with Lung Cancer1 Investigating the Effect of 12-Week Swim Training and Vitamin C Supplementation on TGF-β Expression in Lung Tissue of Mice with Lung CancerenZahraSheykhiPhD student in the Department of Exercise Physiology, Sh.C., Islamic Azad University, Shiraz, IranSeyed Ali HosseiniFaculty of Exercise Physiology, Marv.C., Islamic Azad University, Marvdasht, Iran0000000191223952MehrzadMoghadasiFaculty of Exercise Physiology, Sh.C., Islamic Azad University, Shiraz, Iran2025101Introduction: Lung cancer involves dysregulation of key signaling pathways, including transforming growth factor-beta (TGF-β). This study examined the effect of 12-week swim training (ST) and vitamin C (VC) supplementation on TGF-β expression in the lung tissue of mice with lung cancer. Materials and Methods: 42 male Balb/c mice were assigned to seven groups: healthy control (HC), lung cancer control (LC), VC50, VC100, ST, ST+VC50, and ST+VC100. Lung cancer was induced by benzo[a]pyrene injection. The ST protocol was conducted for 12 weeks, 3 sessions/week. VC was administered orally daily. TGF-β mRNA expression was measured using real-time PCR. Data were analyzed by independent t-test and two-way ANOVA with Bonferroni post-hoc test (p≤0.05). Results: Cancer induction significantly increased TGF-β expression in the LC group (2.44 ± 0.14) compared to HC (1.00 ± 0.025; p=0.001). ST alone significantly reduced TGF-β (1.76 ± 0.10) versus LC (p=0.002). A significant interaction was found between ST and VC on TGF-β reduction (p=0.028), with the lowest expression in ST+VC100 (1.05 ± 0.06) and ST+VC50 (1.12 ± 0.11) groups. Conclusion: The combination of ST and VC synergistically reduces TGF-β expression in a lung cancer model, suggesting a promising complementary therapeutic strategy.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385182026125Women, Menopause, Exercise Therapy StrategiesWomen, Menopause, Exercise Therapy StrategiesenMasoumehHosseiniDepartment of Physical Education and Sport Sciences, ET.C., Islamic Azad University, Tehran, Iran 0000000184571924QazalMarvastiniaDepartment of Physical Education and Sport Sciences, ET.C., Islamic Azad University, Tehran, Iran 00000002686858222025108 Menopause represents a natural physiological transition from the reproductive stage to permanent infertility and is accompanied by a wide range of physical, psychological, and social changes that substantially influence women’s quality of life (1). Clinically, menopause is defined as the permanent cessation of menstruation resulting from the loss of ovarian follicular activity and a marked decline in estrogen production (2). This hormonal alteration is associated with vasomotor symptoms such as hot flashes and night sweats, sleep disturbances, impaired concentration, and mood disorders. Over the long term, menopause is linked to an increased risk of cardiovascular disease, stroke, and osteoporosis (3). The decline in estrogen levels during menopause, combined with increased visceral fat accumulation and weight gain, significantly elevates cardiovascular risk (4). Aging, reduced physical activity, and psychosocial stressors further contribute to unfavorable changes in body composition during this period. Notably, women experience an annual loss of approximately 1–2% of skeletal muscle mass after the age of 40, which adversely affects metabolic health, physical function, and long-term independence (5). Osteoporosis is the most prevalent metabolic bone disorder in postmenopausal women, affecting more than half of women over the age of 50 (6). This condition is characterized by a reduction in bone mineral density and deterioration of bone microarchitecture, leading to an increased risk of fractures. Epidemiological evidence indicates that women are nearly eight times more likely than men to develop osteoporosis, emphasizing the need for preventive strategies (7). Among non-pharmacological interventions, regular physical activity plays a pivotal role in mitigating menopausal complications. Consistent exercise improves cardiovascular and bone health, enhances metabolic rate, reduces abdominal adiposity, improves sleep quality, and promotes psychological well-being (8). Long-term adherence to structured exercise programs may also reduce the incidence of cardiovascular disease in postmenopausal women (9). Various exercise modalities have demonstrated benefits in alleviating menopausal symptoms. Mind–body exercises such as yoga have been shown to reduce blood pressure and improve flexibility and sleep quality. Aerobic exercises enhance cardiac and pulmonary function, while resistance training is particularly effective in preserving muscle mass, improving metabolic health, and reducing the risk of osteoporosis, cardiovascular disease, and type 2 diabetes. Resistance-based exercises have also been associated with improved mental health outcomes in postmenopausal women (10-14). In conclusion, given the well-established benefits of exercise and the minimal adverse effects associated with most physical activity modalities, transitioning from a sedentary lifestyle to regular physical activity is essential for alleviating menopausal symptoms and promoting long-term health. It is recommended that postmenopausal women adopt individualized and supervised exercise programs to reduce menopause-related complications and enhance overall quality of life.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385182026125The Effect of Moderate-Intensity Aerobic Exercise on Fasting Blood Sugar (FBS) and Hemoglobin A1c (HbA1c) Levels in Women with Type 2 DiabetesThe Effect of Moderate-Intensity Aerobic Exercise on Fasting Blood Sugar (FBS) and Hemoglobin A1c (HbA1c) Levels in Women with Type 2 DiabetesenAlireza Babaei Mazreno PhD Student, Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Iran0000000161595536Farzaneh TaghianDepartment of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, Irankhosro Jalali Dehkordi Department of Sports Physiology, Isf.C., Islamic Azad University, Isfahan, IranEsmaeil Babaei Assistant Professor of Ophthalmology, Geratric, Shahid Sadoughi University of Medical Science, Yazd, Iran202576Background and Purpose: Type 2 diabetes is one of the most common chronic metabolic diseases, characterized by impaired glucose metabolism. This study aimed to investigate the effect of moderate-intensity aerobic exercise on fasting blood sugar (FBS) and hemoglobin A1c (HbA1c) levels in women with type 2 diabetes. Methods: This quasi-experimental study employed a pretest-posttest control group design. Thirty women with type 2 diabetes, aged 40 to 50 years, were purposefully selected from the Diabetes Center of Yazd Province and randomly assigned to either the training group (n = 15) or the control group (n = 15). The training group performed moderate-intensity aerobic exercises for 8 weeks. Data were analyzed using paired and independent t-tests at a significance level of 0.05. Results: The findings showed that after the exercise intervention, the training group experienced a significant reduction in FBS and HbA1c levels (p < 0.001), whereas no significant change was observed in the control group (p > 0.05). Moreover, the independent t-test confirmed significant differences between the two groups in the reduction of both indices. Conclusion: Moderate-intensity aerobic exercise, as a non-pharmacological intervention, can play a significant role in improving FBS and HbA1c levels in women with type 2 diabetes and should be considered in the treatment programs for these patients.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385182026125Protective effect of regular physical activity on prostate cancer complicationsProtective effect of regular physical activity on prostate cancer complicationsen Fatemeh Jamshidirad Department of Exercise physiology, CT.C, Islamic Azad University, Tehran, Iran.Hassan Matin Homaee Department of Exercise physiology, CT.C, Islamic Azad University, Tehran, Iran.Mohammad AliAzarbayjaniDepartment of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran 00000002350274872025103Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity among men worldwide. Although the number of deaths from this cancer has decreased over the past decade, the incidence of PCa continues to rise globally. In addition to non-modifiable risk factors, modifiable risk factors such as diet, tobacco and alcohol consumption, obesity, and physical inactivity play a significant role in the development of PCa. Daily physical activity is an important factor in PCa risk, and incorporating it into the daily routine of healthy individua ls can substantially reduce the likelihood of developing PCa, while in affected individuals, it can significantly slow disease progression. Reviewing the results of studies investigating the effects of various exercise programs on PCa demonstrates that regular physical activity can markedly reduce the negative impacts of PCa. These changes occur both at the prostate tumor level, slowing tumor growth, and can also modulate treatment-related side effects such as quality of life (QoL), physical function capacity, muscle mass, sexual function, and fatigue. Regular physical activity exerts its protective effects in PCa patients through improving metabolic status, enhancing antioxidant defense capacity, increasing tumor growth-inhibiting myokines, and a range of other biological mechanisms. Based on the findings of this study, it is recommended that regular physical activity, particularly a combination of aerobic and resistance training, be integrated as an essential component of the management process for individu als with PCa.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385182026125The Effect of Panouol Herbal Supplement Consumption on RBM24 Gene Expression in a Mouse Model of Parkinson’s Disease Following Aquatic ExerciseThe Effect of Panouol Herbal Supplement Consumption on RBM24 Gene Expression in a Mouse Model of Parkinson’s Disease Following Aquatic ExerciseenZahraAmrollahPh.D. Candidate, Department of Sport Physiology, Isf.C., Islamic Azad University, Isfahan, IrankhosroJalali DehkordiDepartment of Sport Physiology, Isf.C., Islamic Azad University, Isfahan, IranShahinRiyahi Malayeri Department of Physical Education and Sport Sciences, ET.C., Islamic Azad University, Tehran, Iran FarzanehTaghianDepartment of Sport Physiology, Isf.C., Islamic Azad University, Isfahan, Iran20251021Background: RBM24 is an RNA-binding protein involved in neuronal differentiation, RNA stability, and adult neurogenesis. Dysregulation of RBM24 has been associated with impaired neural regeneration and enhanced neurodegenerative processes, which are key pathological features of Parkinson’s disease. Considering the neuroprotective effects of exercise and herbal antioxidants, this study aimed to investigate the combined effects of aquatic exercise and Panoeol herbal supplementation on RBM24 gene expression in a mouse model of Parkinson’s disease. <table> <tbody> <tr> <td width="550">   </td> </tr> </tbody> </table> Materials and Methods:Thirty male mice were randomly assigned to five groups: healthy control, Parkinson’s, Parkinson’s + aquatic exercise, Parkinson’s + Panoeol supplementation, and Parkinson’s + aquatic exercise combined with Panoeol supplementation. The aquatic exercise protocol was performed for six weeks, and Panoeol supplementation was administered daily. At the end of the intervention, brain tissue was collected, and RBM24 gene expression was quantified using real-time PCR. Results:Parkinson’s induction significantly decreased RBM24 gene expression compared to the healthy control group. Both aquatic exercise and Panoeol supplementation independently increased RBM24 expression; however, the greatest increase was observed in the combined intervention group (p < 0.05). Conclusion:The combination of aquatic exercise and Panoeol supplementation effectively increases RBM24 gene expression in a Parkinson’s disease mouse model. These findings suggest that RBM24 may play a key mechanistic role in the neuroprotective effects of exercise and herbal supplementation and could serve as a potential therapeutic target for slowing neurodegeneration in Parkinson’s disease.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385182026125Effect of Swimming Exercise and Royal Jelly on MAPK and MMP-9 Gene Expression in Lung Tissue of Benzo[a]pyrene-Induced Lung Cancer Mouse ModelEffect of Swimming Exercise and Royal Jelly on MAPK and MMP-9 Gene Expression in Lung Tissue of Benzo[a]pyrene-Induced Lung Cancer Mouse Modelen SepidehRajabi BanianiDepartment of sport sciences, Shi.C., Islamic Azad University, Shiraz, IranSeyed AliHosseiniDepartment of sport sciences, Marv.C., Islamic Azad University, Marvdasht, IranMehrzad MoghadasiDepartment of sport sciences, Shi.C., Islamic Azad University, Shiraz, Iran20251116Background and Objectives: Lung cancer is one of the most prevalent cancers with a high mortality rate. Mitogen-Activated Protein Kinase (MAPK) and (Matrix Metalloproteinase-9) MMP-9 pathways play crucial roles in inflammation, oxidative stress, and cellular invasion. This study aimed to investigate the effects of swimming exercise and royal jelly on the gene expression of MAPK and MMP-9 in the lung tissue of mice with benzo[a]pyrene-induced lung cancer. Materials and Methods: In this experimental study, 48 male Balb/C mice aged eight weeks were divided into eight groups: healthy control, lung cancer (BZP), , lung cancer + swimming training (ST), , lung cancer + royal jelly 50 mg/kg (RJ50), , lung cancer + royal jelly 100 mg/kg (RJ100), , lung cancer + swimming + royal jelly 50 mg/kg (ST.RJ50), and , lung cancer + swimming + royal jelly 100 mg/kg (ST.RJ100). Lung cancer was induced by intraperitoneal injection of benzo[a]pyrene at 100 mg/kg body weight. Swimming training was performed 3 days per week for 12 weeks. Royal jelly was administered intraperitoneally at doses of 50 and 100 mg/kg body weight. Forty-eight hours after the last session, mice were sacrificed, lung tissues were harvested, and gene expression of MAPK and MMP-9 was measured using real-time PCR. Results: Lung cancer induction significantly increased MAPK and MMP-9 expression. Individual interventions, including swimming and royal jelly at 100 mg/kg, partially reduced MAPK and MMP-9 expression. However, the combination of swimming exercise with royal jelly, particularly at the higher dose (ST.RJ100), produced the greatest reduction in the expression of both genes. Conclusion: The combination of regular exercise with royal jelly, especially at higher doses, has a synergistic effect in reducing MAPK pathway activity and MMP-9 expression. This combination may serve as a preventive and complementary natural strategy to control lung cancer progression and invasion. These findings highlight the importance of simultaneous non-pharmacological interventions with antioxidant and anti-inflammatory effects to improve molecular pathways related to cancer and enhance disease management.

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