مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925Effect of Moderate Aerobic Exercise Combined with Cannabinoid Supplementation on P53 Gene Expression in Rats with High-Fat Diet-Induced Non-alcoholic fatty liver disease (NAFLD)Effect of Moderate Aerobic Exercise Combined with Cannabinoid Supplementation on P53 Gene Expression in Rats with High-Fat Diet-Induced Non-alcoholic fatty liver disease (NAFLD)110enMasoumehMohamadkhaniDepartment of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran0000-0002-0785-1831MandanaGholamiDepartment of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran0000-0001-8960-4123HeshmatolahParsianDepartment of Physical Education and Sport Sciences, shahr-e-Qods Branch, Islamic Azad University, Iran.0009-0009-5088-4696Hossein AbednatanziDepartment of Physical Education and Sport Sciences, SR.C., Islamic Azad University, Tehran, Iran2025612Introduction: In the present study, changes in P53 gene expression were investigated in rats fed a high-fat diet (HFD) after 6 weeks of moderate aerobic exercise and cannabinoid supplementation. Methods: In this experimental study, 40 male Wistar rats were divided into 5 groups (n=8 per group): healthy control, high-fat diet (HFD), HFD + aerobic exercise (Tr), HFD + cannabinoid supplement (Sup), and HFD + Tr + Sup. Rats in the HFD group received a special high-fat diet for 2 months before the main protocol. Rats in the exercise groups ran on a rodent treadmill for 6 weeks, 5 days per week. Cannabinoids supplements were administered via gavage at a dose of 100 ng/kg after each exercise session to rats in the supplement group. To confirm Non-alcoholic fatty liver disease (NAFLD) induction based on HFD, the rats’ livers were examined using a Zonecare-Q9 ultrasound device before the start of the exercise and supplementation protocol. Finally, after the exercise and supplementation protocol, the rats were sacrificed, and the P53 variable was measured by Real-Time PCR. For data analysis, an independent t-test, Bonferroni test, and two-way ANOVA were used. Results:  Ultrasound results showed that the high-fat diet in the HFD group induced grade 2 Non-alcoholic fatty liver disease (NAFLD) compare to the healthy control group. In the HFD group, the P53 gene expression in liver tissue was significantly increased in comparison to the healthy control group (p<0.05). Compared to the HFD group, the Sup group showed a significant decrease in P53 (p<0.05). The HFD+Tr and HFD+Tr+Sup groups did not demonstrate a significant effect on P53 in comparison to the HFD group (p<0.05). Conclusion: The high-fat diet can lead to grade 2 Non-alcoholic fatty liver disease (NAFLD), while cannabinoid supplements, by reducing cellular stress and modulating P53 gene expression, may improve cellular signaling processes and provide a basis for developing new therapeutic strategies for liver cancer patients.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925Comparison of Tabata Training Effects on Physical Fitness and Body Composition in Female University Students With Normal Weight and Overweight: A Quali-Experimental StudyComparison of Tabata Training Effects on Physical Fitness and Body Composition in Female University Students With Normal Weight and Overweight: A Quali-Experimental StudyenZahraMirzashaeriDepartment of physical education and sport science, SR.C., Islamic Azad University, Tehran, Iran.0009000025166507FarshadGhazalianDepartment of physical education and sport science, SR.C., Islamic Azad University, Tehran, Iran.0000-0002-5805-0559Shahin SalehiDepartment of Sports and Exercise Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.0000-0002-2874-0436202586Introduction: Sedentary behavior among female university students is on the rise, often associated with weight gain and reduced physical fitness. Tabata training, a high-intensity interval training (HIIT) modality, was examined for its impact on body composition and fitness parameters in normal-weight and overweight female students. Methods: In this study, 52 female students aged 20–25 were randomly divided into four groups: Tabata-normal weight (n=15), Tabata-overweight (n=11), control-normal weight (n=14), and control-overweight (n=12). A Tabata protocol was followed by the training groups for 8 weeks (3 sessions a week). The outcome measures included body weight, BMI, body fat percentage, VO2max, vertical jump height, and agility (4×9 m shuttle run). The data were analyzed using repeated-measure ANOVA and Bonferroni post-hoc tests. Results: Body weight (P=0.014), BMI (P=0.017), fat percentage (P=0.009), and VO2max (P=0.021) all showed significant main effects, with group-by-time interactions also significant (P&lt;0.05). Only the overweight Tabata group showed statistically significant improvements. Vertical jump (P=0.312) and agility (P=0.281) did not show any significant differences. Conclusion: In overweight female students, an 8-week Tabata-based HIIT program significantly improved body composition and aerobic capacity, which supports its application in academic settings as an efficient and accessible fitness strategy.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925The Effect of Turmeric and Ginger Herbal Plants on Endurance Performance in Athletes: A Systematic ReviewThe Effect of Turmeric and Ginger Herbal Plants on Endurance Performance in Athletes: A Systematic Review2143enZahraMorteza PourDepartment of Sport Physiology, CT.C., Islamic Azad University, Tehran, Iran. 0000000301058768ElhamFarhadfarDepartment of Physical Education and Sport Sciences, Dez.C., Islamic Azad University, Dezful, Iran.0000-0002-9172-4818Zahra SarlakDepartment of Physical Education and Sport Sciences, Khod.C., Islamic Azad University, khodabandeh, Iran.0000-0002-1286-63252025812Introduction: Intense endurance exercises, while improving cardiovascular performance and positive metabolic adaptations, often lead to increased oxidative stress, systemic inflammation, and muscle damage. This can delay recovery and negatively affect optimal athletic performance. In this context, the use of natural nutritional interventions with antioxidant and anti-inflammatory properties—especially herbal supplements such as turmeric (Curcuma longa) and ginger (Zingiber officinale)—is expanding as a natural intervention. The main bioactive compounds in these plants, such as curcumin in turmeric and gingerol in ginger, effectively reduce inflammation, control muscle pain, and improve recovery. This is done by inhibiting inflammatory pathways including NF-κB and COX-2 and decreasing inflammation markers like CRP and IL-6. Methods: This study employed a systematic review method based on the PRISMA protocol. It examined published studies between 1992 and 2024 from reputable scientific databases including PubMed, Scopus, the Web of Science, Google Scholar, and SID. From the 200 initially identified articles, 72 studies met preliminary eligibility criteria. After applying the inclusion and exclusion criteria, 46 articles were selected for the final analysis. Inclusion criteria comprise human or animal studies focusing on the effects of turmeric and ginger on endurance performance, inflammation, muscle pain, and recovery. Results: The results showed that supplementation with turmeric and ginger significantly reduces delayed-onset muscle soreness (DOMS), lowers inflammatory marker levels, improves aerobic capacity, and facilitates muscle glycogen resynthesis. Moreover, some studies confirmed a synergistic effect of the combined consumption of these two herbs on enhancing anti-inflammatory responses and accelerating recovery. Conclusion: Based on this systematic review, turmeric and ginger supplementation appears to be a safe, natural, and effective nutritional strategy for improving endurance performance and recovery in athletes. However, there remains a need for more rigorously designed clinical trials to determine the optimal dosage, pharmaceutical form, and duration of use.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925The Simultaneous effect of high-intensity interval training (HIIT) and omega-3 supplementation on malondialdehyde (MDA) levels in the serum of obese male rats.The Simultaneous effect of high-intensity interval training (HIIT) and omega-3 supplementation on malondialdehyde (MDA) levels in the serum of obese male rats.4452enZohreh NasirizadehDepartment of physical education and sport science,Ya. C., Islamic Azad University, Yazd, Iran.0009-0001-6774-3963AbbasFattahi BafghiDepartment of physical education and sport science,Ya. C., Islamic Azad University, Yazd, Iran.2025731Introduction: High-intensity interval training (HIIT) and omega-3 supplementation are effective strategies to reduce obesity-induced oxidative stress. Malondialdehyde (MDA) serves as a key marker of oxidative damage and helps us learn about these interventions' effectiveness. the aim of this study is to examine the effect of omega-3 fatty acids on Malondialdehyde (MDA) level in long-term aerobic exercise in the serum of obese rats. Methods: In a semi-experimental and applied study, 40 obese male rats of 6 months with Wistar breed with a weighted average of 332.28 Grams and standard deviation of 9 after 7 days of acquaintance with the laboratory environment were randomly divided into 4 groups of 10 (control, training, supplement and training-supplement). The training-supplementation and training groups underwent aerobic training for 6 weeks and 4 sessions in each week, according to the training protocol. Supplement and training- Supplements Groups also for 6 weeks and 4 meals every week, one hour before the start of training, 400 mg of omega-3 per kilogram of body weight was gavage. 24 hours after the last training session, while fasting for 12 hours, all subjects were anesthetized with ketamine and xylazine solution and blood was taken from the posterior orbital sinus of the rats. The collected blood samples were immediately transferred to the laboratory to measure the variables. In order to analyze the data at the descriptive level, mean and standard deviation tests were used, and at the inferential level, the Shapiro-Wilk test was used to check the normality of the data, and the two-way ANOVA test was used to check the interaction effect of the groups. data analysis It was done using spss software version 26 and at a significance level(P≤0.05). Results: The statistical results of the study showed that all three variables of intensity interval training, Omega-3 supplementation, and exercise-supplementation caused a significant decrease in serum levels of the enzyme malondialdehyde. (p < 0.05). Conclusion: Based on the results of the present study, it seems that the interactive effect of endurance training and omega-3 supplementation can be used to reduce oxidative damage caused by obesity in the body.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925Aerobic training affects the expression of oncogenic genes in prostate tissue in male ratsAerobic training affects the expression of oncogenic genes in prostate tissue in male rats5362en Hossein ManzouriDepartment of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran.0000000172061919HasanMatinhomaeeDepartment of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran.Mohammad AliAzarbayjaniDepartment of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran.0000-0002-3502-74872025820Introduction: Since the effect of aerobic training on MMP-9 and MMP-2 gene expression in prostate tissue under cancer conditions is unknown, the present study was conducted to establish the effect of aerobic training on MMP-9 and MMP-2 gene expression in prostate tissue of male rats. Methods: In an experimental study, 30 male Wistar rats were randomly divided into 3 groups: 1-control-healthy group, 2-control-prostate cancer group, and 3-prostate cancer-aerobic training group. After prostate cancer was induced using LNCaP and TSP-1-EnSC cell lines, the subjects underwent aerobic training for eight weeks. After prostate cancer was induced using LNCaP and TSP-1-EnSC cell lines, the subjects underwent aerobic training for eight weeks. At the end of the eighth week, the rats were sacrificed and their prostate tissue was removed. This was done to measure MMP-9 and MMP-2 gene expression by Real Time PCR. Results: The results showed that MMP-9 gene expression (P=0.006) was considerably higher in the control-prostate cancer induction group than in the control-healthy group. MMP-9 gene expression (P=0.009) was significantly lower in the prostate cancer-aerobic training group than in the control prostate cancer group. MMP-2 gene expression (P=0.006) was significantly lower in the prostate cancer-aerobic training group than in the control prostate cancer induction group. The results of the present study show that prostate cancer induction is associated with increased expression of MMP-2 and MMP-9 genes, known as oncogenic genes. Conclusion: Aerobic training reduces the expression of MMP-9 and MMP-2 genes, which indicates that aerobic training in induced prostate cancer can prevent prostate tumor development by inhibiting the expression of oncogenic genes, so it is recommended to use aerobic training in prostate cancer conditions.

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مرکز منطقه ای اطلاع رسانی علوم و فناوریJournal of Sports Physiology and Athletic Conditioning2783-30385172025925 The effect of 8 weeks of hydrotherapy and land based exercises on strength, balance, range of motion and pain reduction in elderly women with history of both knees replacement The effect of 8 weeks of hydrotherapy and land based exercises on strength, balance, range of motion and pain reduction in elderly women with history of both knees replacement 6379enBehnazHajirezaeiDepartment of Sport Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.RIbeh115458Abdolrasoul DaneshjooDepartment of Sport Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.0000-0003-4410-0840Ali RezaIzadiDepartment of Sport Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.00000001595869562025325Background & Aims: Exercise program after knee replacement surgery improves postoperative pain, length of hospital stay, and health-related quality of life. However, the effectiveness of postoperative interventions has been different with the type of intervention protocols. The main purpose of this study was to investigate the effect of 8 weeks hydrotherapy and land based exercise on strength, balance, range of motion and pain reduction in elderly women with history of both knees replacement. Methods: In this semi-experimental study, 30 elderly women with history of both knees replacement from Tehran were selected and randomly divided into three groups: land exercise, hydrotherapy exercise and control. The training program consisted of three sessions per week, each session lasting 60 minutes, including flexibility exercise, movement coordination and agility, balance exercise (perception of space, time and reaction speed) and strength exercise for eight weeks on land and water. The subjects were tested for strength, balance, range of motion and pain level before and after the training. To compare the results of the groups, were used one-way analysis of variance and Tukey's post hoc test at the P<0.05. Results: The results showed that eight weeks of hydrotherapy and land based exercise have significant effect on strength, balance, range of motion and the amount of pain reduction in elderly women with history of both knees replacement (p=0.001), but there was no significant difference between changes in strength, balance, range of motion and pain reduction between the two experimental groups (P<0.05). Conclusion: According to the results, it is possible to recommend hydrotherapy and land based exercise interventions to improve strength, balance, range of motion and reduce pain in patients with history of both knees replacement.

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