jspac-202605280220260528020915CMV Verlagkhoffmann@cmv-verlag.comCMV Verlag Journal of Sports Physiology and Athletic Conditioningjspac2783-303812202337MasoumehHosseiniHamid Vakilian 122023122210.52547/jspac.39048.3.7.12http://jspac.etb.iau.ir/en/Article/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/39048http://jspac.etb.iau.ir/en/Article/Download/390481. Stein, Angelica Miki et al. Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly. Dementia & Neuropsychologia [online]. 2018, v. 12, n. 2 [Accessed 19 December 2022], pp. 114-122. Available from: <https://doi.org/10.1590/1980-57642018dn12-020003>. ISSN 1980-5764. https://doi.org/10.1590/1980-57642018dn12-020003.2. Majorczyk M, Smoląg D. Effect of physical activity on IGF-1 and IGFBP levels in the context of civilization diseases prevention. Rocz Panstw Zakl Hig. 2016;67(2):105-11. PMID: 27289505.3. Nindl BC, Santtila M, Vaara J, Hakkinen K, Kyrolainen H. Circulating IGF-I is associated with fitness and health outcomes in a population of 846 young healthy men. Growth Horm IGF Res. 2011 Jun;21(3):124-8. doi: 10.1016/j.ghir.2011.03.001. Epub 2011 Apr 2. PMID: 21459641.4. Puche JE, Castilla-Cortázar I. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. doi: 10.1186/1479-5876-10-224. PMID: 23148873; PMCID: PMC3543345.5. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 2001 Nov;3(11):1009-13. doi: 10.1038/ncb1101-1009. PMID: 11715022.6. Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 2003 Jun 1;17(11):1352-65. doi: 10.1101/gad.1089403. PMID: 12782654; PMCID: PMC196068.7. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8. doi: 10.1126/science.1065874. Epub 2001 Oct 25. PMID: 11679633..8. Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res. 2014 May;28(5):633-42. doi: 10.1002/ptr.5045. Epub 2013 Aug 7. PMID: 23922235..9. Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M, Ferns GA. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res. 2013 Mar;27(3):374-9. doi: 10.1002/ptr.4715. Epub 2012 May 21. PMID: 22610853..10. Hedayati S, Riyahi Malayeri S, Hoseini M. The Effect of Eight Weeks of High and Moderate Intensity Interval Training Along with Aloe Vera Consumption on Serum Levels of Chemerin, Glucose and Insulin in Streptozotocin-induced Diabetic Rats: An Experimental Study. JRUMS 2018; 17 (9) :801-814. URL: http://journal.rums.ac.ir/article-1-4209-en.html.11. Hosseini M, Eftekhar B, Riyahi Malayeri S. Effect of Interval Training with Curcumin Consumption on Some Adipokines in Menopausal Obese Rats. JRUMS 2017; 16 (6) :505-516. URL: http://journal.rums.ac.ir/article-1-3644-en.html.12. Riyahi Malayeri S, Abdolhay S, Behdari R, Hoseini M. The combined effect of resveratrol supplement and endurance training on IL-10 and TNF- α in type 2 diabetic rats. RJMS 2019; 25 (12) :140-149. URL: http://rjms.iums.ac.ir/article-1-5526-en.html13. Arabzadeh E, Shirvani H, Ebadi Zahmatkesh M, Riyahi Malayeri S, Meftahi GH, Rostamkhani F. Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats. 3 Biotech. 2022 Sep;12(9):193. doi: 10.1007/s13205-022-03253-9. Epub 2022 Jul 26. PMID: 35910290; PMCID: PMC9325938.14. Osali A. Effect of six -week aerobic exercise and consumption of nanocurcumin on TNF-α and memory in 60-65 years old women with metabolic syndrome. Koomesh. 2018; 20 (3) :503-509.15. El-Bahr S M. Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats. BMC complementary and alternative medicine 2013; 13(1): 1-11.16. Rashidi E, Hosseini Kakhak S A R, Askari R. The Effect of 8 Weeks Resistance Training With Low Load and High Load on Testosterone, Insulin-like Growth Factor-1, Insulin-like Growth Factor Binding Protein-3 Levels, and Functional Adaptations in Older Women. Salmand: Iranian Journal of Ageing 2019; 14 (3) :356-367. URL: http://salmandj.uswr.ac.ir/article-1-1498-en.html.17. Vakili J, Sari Sarraf V, Khanvari T. Effects of High-intensity Interval Training on Body Composition and Hormone Growth Agents in Overweight Adolescent Boys. J Arak Uni Med Sci 2021; 24 (1) :136-149.18. Sarmadiyan M, Khorshidi D. Effect of combined training on body composition, lipids levels and indicators of metabolic syndrome in overweight and obesed postmenopausal women. joge 2016; 1 (2) :36-44URL: http://joge.ir/article-1-100-en.htmlGholamrezaRostamiHaider SadeghiYahya Sokhanguei122023364910.52547/jspac.39093.3.7.36http://jspac.etb.iau.ir/en/Article/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/39093http://jspac.etb.iau.ir/en/Article/Download/390931. Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018 Aug 31;17(1):122. doi: 10.1186/s12933-018-0762-4. PMID: 30170598; PMCID: PMC61192422. Riyahi Malayeri S, Azadniya A, Rasaee M J. EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING AND RESVERATROL INTAKE ON SERUM ADIPONECTIN AND RESISTIN IN TYPE 2 DIABETIC RATS. ijdld 2019; 18 (1) :8-1. URL: http://ijdld.tums.ac.ir/article-1-5708-en.html.3. Keihani, D., Kargarfard, M., Mokhtari, M. Cardiac effects of exercise rehabilitation on quality of life, depression and anxiety in patients with heart failure patients. Journal of Fundamentals of Mental Health, 2014; 17(1): 13-19. doi: 10.22038/jfmh.2014.37804. Kusuma Venkatesh, Deepak DC, Venkatesha VT. Postmortem Study of Hearts – Pathology of Coronary Artery Atherosclerosis. J Forensic Sci & Criminal Inves. 2019; 12(4): 555843. doi: 10.19080/JFSCI.2018.11.555843.5. LaPier TK. Functional status of patients during subacute recovery from coronary artery bypass surgery. Heart Lung. 2007 Mar-Apr;36(2):114-24. doi: 10.1016/j.hrtlng.2006.09.002. PMID: 17362792.6. Inthavong, R., Khatab, K., Whitfield, M., Collins, K., Ismail, M. and Raheem, M. The Impact of Risk Factors Reduction Scenarios on Hospital Admissions, Disability-Adjusted Life Years and the Hospitalisation Cost of Cardiovascular Disease in Thailand. Open Access Library Journal,2020; 7, 1-21. doi: 10.4236/oalib.1106160.7. Gaieni, A. and et al, The comparison of eight weeks of combined and aerobic training on functional capacity, body composition and strength in post-coronary artery bypass graft cardiac patients. Iranian Journal of Cardiovascular Nursing, 2013. 2(1): p. 34-41. URL: http://journal.icns.org.ir/article-1-148-en.html8. Ito F. Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism. Curr Mol Pharmacol. 2021;14(2): 175190.doi:10.2174/1874467213666200320153410. PMID: 32196455.9. Masumeh Baghban Baghdadabad, et al., The effect of two methods of aerobic and parallel training on selected blood biomechanical variables in bilateral femoral artery in patients 40-65 years old after coronary angioplasty. J Rehab Med., 2019. 8(1): p. 95-102.10. Milutinović A, Šuput D, Zorc-Pleskovič R. Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review. Bosn J Basic Med Sci. 2020 Feb 5;20(1):21-30. doi: 10.17305/bjbms.2019.4320. PMID: 31465719; PMCID: PMC7029210.11. Otsuka F, Yasuda S, Noguchi T, Ishibashi-Ueda H. Pathology of coronary atherosclerosis and thrombosis. Cardiovasc Diagn Ther. 2016 Aug;6(4):396-408. doi: 10.21037/cdt.2016.06.01. PMID: 27500096; PMCID: PMC4960071.12. Bauersachs R, Zeymer U, Brière JB, Marre C, Bowrin K, Huelsebeck M. Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review. Cardiovasc Ther. 2019 Nov 26; 2019:8295054. doi: 10.1155/2019/8295054. PMID: 32099582; PMCID: PMC7024142.13. Song, P., et al., Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Glob Health, 2019. 7(8): p. e1020-e1030. doi.org/10.1016/S2214-109X (19)30255-414. Mangell P, Länne T, Sonesson B, Hansen F, Bergqvist D. Regional differences in mechanical properties between major arteries--an experimental study in sheep. Eur J Vasc Endovasc Surg. 1996 Aug;12(2):189-95. doi: 10.1016/s1078-5884(96)80105-5. PMID: 8760981.15. Wang JC, Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res. 2012 Jul 6;111(2):245-59. doi: 10.1161/CIRCRESAHA.111.261388. PMID: 22773427.16. Vecoli C, Borghini A, Andreassi MG. The molecular biomarkers of vascular aging and atherosclerosis: telomere length and mitochondrial DNA4977 common deletion. Mutat Res Rev Mutat Res. 2020 Apr-Jun; 784:108309. doi: 10.1016/j.mrrev.2020.108309. Epub 2020 Apr 25. PMID: 32430098.17. Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views. 2017 Jul-Sep;18(3): 109-114.doi: 10.4103/HEARTVIEWS.HEARTVIEWS_106_17. PMID: 29184622; PMCID: PMC5686931.18. Huang G, Gibson CA, Tran ZV, Osness WH. Controlled endurance exercise training and VO2max changes in older adults: a meta-analysis. Prev Cardiol. 2005 Fall;8(4):217-25. doi: 10.1111/j.0197-3118.2005.04324. x. PMID: 16230876.19. Soer R, Brouwer S, Geertzen JH, van der Schans CP, Groothoff JW, Reneman MF. Decline of functional capacity in healthy aging workers. Arch Phys Med Rehabil. 2012 Dec;93(12):2326-32. doi: 10.1016/j.apmr.2012.07.009. Epub 2012 Jul 25. PMID: 22842482.20. Roh JD, Houstis N, Yu A, Chang B, Yeri A, Li H and et al. Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell. 2020 Jun;19(6): e13159. doi: 10.1111/acel.13159. Epub 2020 May 22. PMID: 32441410; PMCID: PMC7294786.21. Zand S, khajehgoodari M, Rafiei M, Rafiei F. Effect of walking at home on heart functioning levels of people with heart failure. PCNM. 2016; 6 (2): 13-23.URL: http://zums.ac.ir/nmcjournal/article-1-352-en.html22. Figueroa A, Jaime SJ, Morita M, Gonzales JU, Moinard C. L-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults. Exerc Sport Sci Rev. 2020 Jul;48(3):133-139. doi: 10.1249/JES.0000000000000223. PMID: 32568925.23. Kohn JC, Chen A, Cheng S, Kowal DR, King MR, Reinhart-King CA. Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise. J Biomech. 2016 Jun 14;49(9):1447-1453. doi: 10.1016/j.jbiomech.2016.03.016. Epub 2016 Mar 16. PMID: 27020750; PMCID: PMC4885756.24. Jamshidi L, Seif A. Comparison of cardiovascular diseases risk factors in male and female older adults of Hamadan City, 2014. joge. 2016; 1 (1) :1-10. URL: http://joge.ir/article-1-41-en.html25. Riyahi Malayeri S, Abdolhay S, Behdari R, Hoseini M. The combined effect of resveratrol supplement and endurance training on IL-10 and TNF- α in type 2 diabetic rats. RJMS 2019; 25 (12) :140-149.URL: http://rjms.iums.ac.ir/article-1-5526-en.html.26. Chen J, Guo Y, Gui Y, Xu D. Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases. Lipids Health Dis. 2018 Jan 22;17(1):17. doi: 10.1186/s12944-017-0653-9. PMID: 29357881; PMCID: PMC5778620.27. Wisløff U, Ellingsen Ø, Kemi OJ. High-intensity interval training to maximize cardiac benefits of exercise training? Exerc Sport Sci Rev. 2009 Jul;37(3):139-46. doi: 10.1097/JES.0b013e3181aa65fc. PMID: 19550205.28. Saremi A, Farahani A A, Shavandi N. Cardiac Adaptations (Structural and Functional) to Regular Mountain Activities in Middle-aged Men. J Arak Uni Med Sci. 2017; 20 (6): 31-40.URL: http://jams.arakmu.ac.ir/article-1-5140-en.html29. Ehsani AA, Ogawa T, Miller TR, Spina RJ, Jilka SM. Exercise training improves left ventricular systolic function in older men. Circulation. 1991 Jan;83(1):96-103. doi: 10.1161/01.cir.83.1.96. PMID: 1984902.30. Abbas Saremi, Masume Sadeghi, Shahnaz Shahrjerdi, Sonia Hashemi. An eight-weeks cardiac rehabilitation program in patients with coronary artery diseases: Effects on chronic low-grade inflammation and cardiometabolic risk factors. Payesh. 2017; 16 (2) :160-169.URL: http://payeshjournal.ir/article-1-113-en.html.31. Riyahi Malayeri, S., Saei, M. Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese men. Sport Physiology & Management Investigations, 2019; 10(4): 31-42. http://www.sportrc.ir/article_82662.html?lang=en32. bahramian, A., mirzaei, B., Rahmani nia, F., karimzade, F. The Effect of Training Exercise Intensity on Left Ventricular Structure and Function in Rats with Myocardial Infarction. Journal of Sport Biosciences, 2019; 11(3): 315-326. doi: 10.22059/jsb.2019.261967.1295 11(3): p. 315-326.33. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS Jr. Relative intensity of physical activity and risk of coronary heart disease. Circulation. 2003 Mar 4;107(8):1110-6. doi: 10.1161/01.cir.0000052626.63602.58. PMID: 12615787.34. Alsabah Alavizadeh N, Rashidlamir A, Hejazi S M. Effects of Eight Weeks of Cardiac Rehabilitation Training on Serum Levels of Sirtuin1 and Functional Capacity of Post- Coronary Artery Bypass Grafting Patients. mljgoums. 2019; 13 (2) :41-47.URL: http://mlj.goums.ac.ir/article-1-1186-en.html35. Fallahi, A., Nejatian, M., Sardari, A., Piry, H. Comparison of Two Rehabilitate Continuous and Interval Incremental Individualized Exercise Training Methods on Some Structural and Functional Factors of Left Ventricle in Heart Patients after Coronary Artery Bypass Graft Surgery Coronary artery bypass graft. The Scientific Journal of Rehabilitation Medicine, 2017; 6(4): 182-191. doi: 10.22037/jrm.2017.110582.138636. Mirnasuri R, Mokhtari G, Ebadifara M, Mokhtari Z. The effects of cardiac rehabilitation program on exercise capacity and coronary risk factors in Coronary artery bypass graft Patients aged 45-65. yafte. 2014; 15 (5) :72-81.URL: http://yafte.lums.ac.ir/article-1-1495-en.html37. Oliveira, J.L.M., C.M. Galvão, and S.M.M. Rocha, Resistance exercises for health promotion in coronary patients: Evidence of benefits and risks. International Journal of Evidence‐Based Healthcare, 2008. 6(4): p. 431-439. https://doi.org/10.1111/j.1744-1609.2008.00114.x38. Ghroubi S, Elleuch W, Abid L, Abdenadher M, Kammoun S, Elleuch MH. Effects of a low-intensity dynamic-resistance training protocol using an isokinetic dynamometer on muscular strength and aerobic capacity after coronary artery bypass grafting. Ann Phys Rehabil Med. 2013 Mar;56(2):85-101. doi: 10.1016/j.rehab.2012.10.006. Epub 2012 Dec 7. PMID: 23414745.39. Atef, H., Z. Helmy, and A. Farghaly, Effect of different types of exercise on sleep deprivation and functional capacity in middle aged patients after coronary artery bypass grafting. Sleep Science, 2020. 13(2): p. 113. DOI: 10.5935/1984-0063.20190136.PMCID: PMC7384528.40. Green DJ, Hopman MT, Padilla J, Laughlin MH, Thijssen DH. Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli. Physiol Rev. 2017 Apr;97(2):495-528. doi: 10.1152/physrev.00014.2016. PMID: 28151424; PMCID: PMC5539408.Faegheh Jafari AmoliSeyed Ali HosseiniMohammad Ali AzarbayjaniParvin Farzanegi Arkhazloo12202311110.52547/jspac.39658.3.7.1http://jspac.etb.iau.ir/en/Article/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/39658http://jspac.etb.iau.ir/en/Article/Download/396581. Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB; American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2016 Update: A Report from the American Heart Association. Circulation. 2016 Jan 26;133(4):e38-360. doi: 10.1161/CIR.0000000000000350. Epub 2015 Dec 16. Erratum in: Circulation. 2016 Apr 12;133(15):e599. PMID: 26673558.2. Naghavi E-A, Dehghannya J, Ghanbarzadeh B. Effect of hydrocolloid type on transfer phenomena during deep-fat frying of coated potato strips: Numerical modeling and experimental analysis. Comput Electron Agr. 2018;154:382-399.3. Ekiz E, Oz F. The effects of different frying oils on the formation of heterocyclic aromatic amines in meatballs and the changes in fatty acid compositions of meatballs and frying oils. J Sci Food Agric. 2019 Mar 15;99(4):1509-1518. doi: 10.1002/jsfa.9325. Epub 2018 Oct 29. PMID: 30141529.4. Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci. 2015 Feb;143(2):242-55. doi: 10.1093/toxsci/kfu233. PMID: 25628402; PMCID: PMC4306719.5. Basu, S., Choudhury, I.N., Nazareth, L. et al. In vitro modulation of Schwann cell behavior by VEGF and PDGF in an inflammatory environment. Sci Rep 12, 662 (2022). https://doi.org/10.1038/s41598-021-04222-76. Basu S, Choudhury IN, Lee JYP, Chacko A, Ekberg JAK, St John JA. Macrophages Treated with VEGF and PDGF Exert Paracrine Effects on Olfactory Ensheathing Cell Function. Cells. 2022 Aug 4;11(15):2408. doi: 10.3390/cells11152408. PMID: 35954252; PMCID: PMC9368560.7. Kim KB, Kim YA, Park JJ., Effects of 8-week Exercise on Bcl-2, Bax, Caspase-8, Caspase-3 and HSP70 in Mouse Gastrocnemius Muscle. Journal of Life Science. 2010; 20(9): 1409-14.8. Darvishzadeh N, Azizbeigi K, Etemad Z. The Effect of Aerobic Exercises and Octopamine Consumption on Changes in Gene Expression of Caspase-9, NLRP3, AIM2 in Brown Adipose Tissue of Rats after Intoxication with Deep Fried Oil: An Experimental Study. JRUMS 2021; 20 (1):37-52URL: http://journal.rums.ac.ir/article-1-5775-en.html9. Thevis M, Koch A, Sigmund G, Thomas A, Schänzer W. Analysis of octopamine in human doping control samples. Biomed Chromatogr. 2012 May;26(5):610-5. doi: 10.1002/bmc.1705. Epub 2011 Sep 19. PMID: 21932383.10. de Oliveira AL, de Paula MN, Comar JF, Vilela VR, Peralta RM, Bracht A. Adrenergic metabolic and hemodynamic effects of octopamine in the liver. Int J Mol Sci. 2013 Nov 5;14(11):21858-72. doi: 10.3390/ijms141121858. PMID: 24196353; PMCID: PMC3856039..11. de Oliveira AL, de Paula MN, Comar JF, Vilela VR, Peralta RM, Bracht A. Adrenergic metabolic and hemodynamic effects of octopamine in the liver. Int J Mol Sci. 2013 Nov 5;14(11):21858-72. doi: 10.3390/ijms141121858. PMID: 24196353; PMCID: PMC3856039..12. Mahmudi R, Azarbayjani M A, Peeri M , Farzanegi P. Effects of Training and Octopamine Supplementation on Expression of M1 and M2 Monocyte/Macrophage Surface Markers in White Adipose Tissue of Rats Poisoned with Deep-Fried Oil. Gene Cell Tissue.7(1):e100036. doi: 10.5812/gct.100036.13. Kazemi A. Effect of high intensity interval training on visceral and subcutaneous level of MCP-1 and plasma insulin glucose in male rats. RJMS.2017;23(152):29-3.14. Pasavand, P., S. A. Hosseini, and S. Farsi. “Effects of Moderate and High Intensity Endurance Trainings on INFγ and TNFα of Streptozotocin Induced Diabetic Rats”. International Journal of Applied Exercise Physiology, Vol. 7, no. 3, Sept. 2018, pp. 55-67, doi:10.30472/ijaep.v7i3.284.15. Abdollahi S, Mohamadzadeh Salamat K, Azizbeigi K, Etemad Z. The effect of 4 weeks of aerobic training and octapamine on the levels of malondialdehyde and caspase 3 in brown adipose tissue in rats received deeply heated oils treatment. J Jiroft Univ Med Sci 2020; 7(2):394-403URL: http://journal.jmu.ac.ir/article-1-374-en.html16. Khademi Y, Hosseini SA, Dana F, Hamidi A, Azadmanesh M. Effect of high intensity interval training with flaxseed on interleukin-1 beta and lipocalin-2 gene expressions in the heart tissue of rats. J Arch Mil Med. 2019;6(4):e83888.17. Abdollahi S, Salamat K, Azizbeigi K, Etemad Z. The effect of 4 weeks of aerobic training and octopamine on the levels of malondialdehyde and caspase 3 in brown adipose tissue in rats received deeply heated oils treatment. Journal of Jiroft University of Medical Sciences. 2020, 7(2),394-403.18. Wang Z, Liao T, Zhou Z, Wang Y, Diao Y, Strappe P et al. Construction of local gene network for revealing different liver function of rats fed deep-fried oil with or without resistant starch. Toxicol Letters. 2016;258:168-74.19. Zhao D, Tu Y, Wan L, Bu L, Huang T, Sun X, Wang K, Shen B. In vivo monitoring of angiogenesis inhibition via down-regulation of mir-21 in a VEGFR2-luc murine breast cancer model using bioluminescent imaging. PLoS One. 2013 Aug 8;8(8):e71472. doi: 10.1371/journal.pone.0071472. PMID: 23951172; PMCID: PMC3738509.20. Zare zadeh mehrizi AA, rajabi H, Gharakhanlou R,Naghdi N, Azimi dokht SMA. Effect of 8 weeks of aerobic training on genes expression of Hypoxia inducible factor HIF-1α, vascular endothelial growth factor (VEGF) and angiostatin in hippocampus of male rats with Wistar model. J Shahid Sadoughi Uni Med Sci 2020; 27(11): 2063-75.21. Wang X, Yi X, Tang D. Regular aerobic exercise activates PDGF-BB/PDGFR-β signaling and modulates the inflammatory-anti-inflammatory balance in diet-induced obese mice. Obes Res Clin Pract. 2021 Jul-Aug;15(4):387-394. doi: 10.1016/j.orcp.2021.04.003. Epub 2021 May 27. PMID: 34052185.22. Fateme Shokri; Mohammad Ali Azarbayjani; Maghsoud Peeri; Farshad Ghazalian. "The Effect of Octopamine and Aerobic Exerciseand on Genes Affecting Angiogenesis of Visceral Adipose Tissue in Rats Fed with Deep- Fried Oil". Journal of Nutrition,Fasting and Health, 8, 3, 2020, 192-198. doi: 10.22038/jnfh.2020.45028.123823. Esfandiarifar A, Azarbayjani MA, Peeri M, Jameie SB. The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats. Basic Clin Neurosci. 2021 May-Jun;12(3):373-382. doi: 10.32598/bcn.2021.2250.1. Epub 2021 May 1. PMID: 34917296; PMCID: PMC8666922.NedaRomuzi122023637510.52547/jspac.39953.3.7.63http://jspac.etb.iau.ir/en/Article/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/39953http://jspac.etb.iau.ir/en/Article/Download/399531. Shakoor H, Apostolopoulos V, Feehan J, Ali HI, Ismail LC, Al Dhaheri ASOS, Stojanovska L. Effect of Calorie Restriction and Exercise on Type 2 Diabetes. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2021 Apr 23;42(1):109-126. doi: 10.2478/prilozi-2021-0010. PMID: 33894117..2. Hedayati S, Riyahi Malayeri S, Hoseini M. The Effect of Eight Weeks of High and Moderate Intensity Interval Training Along with Aloe Vera Consumption on Serum Levels of Chemerin, Glucose and Insulin in Streptozotocin-induced Diabetic Rats: An Experimental Study. JRUMS 2018; 17 (9) :801-814.URL: http://journal.rums.ac.ir/article-1-4209-en.html3. Riyahi Malayeri S, Azadniya A, Rasaee M J. EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING AND RESVERATROL INTAKE ON SERUM ADIPONECTIN AND RESISTIN IN TYPE 2 DIABETIC RATS. ijdld 2019; 18 (1) :8-1. URL: http://ijdld.tums.ac.ir/article-1-5708-en.html.4. Rehman K, Akash MS. Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci. 2016 Dec 3;23(1):87. doi: 10.1186/s12929-016-0303-y. PMID: 27912756; PMCID: PMC5135788). 5. Riyahi Malayeri S, Abdolhay S, Behdari R, Hoseini M. The combined effect of resveratrol supplement and endurance training on IL-10 and TNF- α in type 2 diabetic rats. RJMS 2019; 25 (12) :140-149. URL: http://rjms.iums.ac.ir/article-1-5526-en.html.6. Jaganathan R, Ravindran R, Dhanasekaran S. Emerging Role of Adipocytokines in Type 2 Diabetes as Mediators of Insulin Resistance and Cardiovascular Disease. Can J Diabetes. 2018 Aug;42(4):446-456.e1. doi: 10.1016/j.jcjd.2017.10.040. Epub 2017 Dec 8. PMID: 29229313..7. Lundberg TR, Howatson G. Analgesic and anti-inflammatory drugs in sports: Implications for exercise performance and training adaptations. Scand J Med Sci Sports. 2018 Nov;28(11):2252-2262. doi: 10.1111/sms.13275. Epub 2018 Sep 2. PMID: 30102811..8. Riyahi Malayeri, S., Saei, M. Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese man. Sport Physiology & Management Investigations, 2019; 10(4): 31-42. http://www.sportrc.ir/article_82662.html?lang=en9. Jeong H, Baek SY, Kim SW, Park EJ, Lee J, Kim H, Jeon CH. C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey. BMJ Open. 2019 Aug 30;9(8):e029861. doi: 10.1136/bmjopen-2019-029861. PMID: 31473619; PMCID: PMC6720331..10. Farazandeh Nia, D., Hosseini, M., Riyahi Malayeri, S., Daneshjoo, A. Effect of Eight Weeks of Swimming Training with Garlic Intake on Serum Levels of IL-10 and TNF-α in Obese Male Rats. Jundishapur Scientific Medical Journal, 2018; 16(6): 665-671. doi: 10.22118/jsmj.2018.5783011. Eckel J. Myokines in metabolic homeostasis and diabetes. Diabetologia. 2019 Sep;62(9):1523-1528. doi: 10.1007/s00125-019-4927-9. Epub 2019 Jul 1. PMID: 31263909..12. Matsui T, Yukiyoshi A, Doi S, Sugimoto H, Yamada H, Matsumoto K. Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J Nutr Biochem. 2002 Feb;13(2):80-86. doi: 10.1016/s0955-2863(01)00198-x. PMID: 11834223..13. Moradi Z, Shmshky A. The effect of supplementation on changes in levels of superoxide dismutase and catalase saffron during intense aerobic exercise in young women. Research in Sport Sciences 2012;14(2):119-30. 14. Etemad Z, Zohali .S. The Effect of Aerobic Training and Royal Jelly Supplementation on Some Inflammatory Markers in Overweight Women. MEJDS 2021;11(21).15. Panahi E, Effect of three-week supplemental supplementation of Royal jelly with aerobic exercise activity on inflammatory CRP indices and changes in IgG1 immunoglobulin levels in inactive women. Master Thesis,Tehran: Al-Zahra University. 2014. 16. Molaei R, Vahidian Razazadeh M, Moghtadri A. Effect of 6 weeks aerobic exercise and oral Royal Jelly consumption on inflammatory factors' multiple sclerosis patients. medicalJournal of Mashad University of medical Sciences 2019;62(3):1524-35. 17. Mousavi SN, Jazayeri Sh, Khoshpay B, Malek M, Hosseini AF, Hosseini Sh, et al. Royal jelly decreases blood pressure, serum glucose, and interleukin-6 in patients with type 2 diabetes on an iso-caloric diet. Journal of Nutrition and Food Security 2017;2(4):300-7. 18. Takahashi Y, Hijikata K, Seike K, Nakano S, Banjo M, Sato Y, Takahashi K, Hatta H. Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle. Nutrients. 2018 Nov 12;10(11):1735. doi: 10.3390/nu10111735. PMID: 30424505; PMCID: PMC6266893..19. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008 Nov;56(11):2045-52. doi: 10.1111/j.1532-5415.2008.01994.x. PMID: 19016938; PMCID: PMC2683336..20. Malekyian Fini E, Shavandi N, Saremi A, Tabibi Rad S. Effect of short-term Resvin supplementation on total antioxidant capacity‚ super oxide dismutase, and creatine kinase in elite women volleyball players. IranianJournal of Nutrition Sciences & Food Technology 2013;7(3):79-86. 21. Büyükipekçi S, Sarıtaş N, Soylu M, Mıstık S, Silici S. Effects of royal jelly and honey mixture on some hormones in young males performing maximal strength workout. Physical Education of Students 2018;22(6):308–15.22. Noura M, Arshadi S , Zafari A , Banaeyfar A. Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease. Middle East J Rehabil Health Stud.7(1):e99754. doi: 10.5812/mejrh.99754..23. Gregersen S, Samocha-Bonet D, Heilbronn LK, Campbell LV. Inflammatory and oxidative stress responses to high-carbohydrate and high-fat meals in healthy humans. J Nutr Metab. 2012;2012:238056. doi: 10.1155/2012/238056. Epub 2012 Feb 13. PMID: 22474579; PMCID: PMC3306970..24. Krook A. IL-6 and metabolism-new evidence and new questions. Diabetologia. 2008 Jul;51(7):1097-9. doi: 10.1007/s00125-008-1019-7. PMID: 18458869.25. Teixeira de Lemos E, Pinto R, Oliveira J, Garrido P, Sereno J, Mascarenhas-Melo F, Páscoa-Pinheiro J, Teixeira F, Reis F. Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus. Mediators Inflamm. 2011;2011:253061. doi: 10.1155/2011/253061. Epub 2011 Nov 15. PMID: 22174491; PMCID: PMC3235883.26. Yang YC, Chou WM, Widowati DA, Lin IP, Peng CC. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells. BMC Complement Altern Med. 2018 Jul 3;18(1):202. doi: 10.1186/s12906-018-2267-9. PMID: 29970062; PMCID: PMC6029378..27. Asgari M, Asle-Rousta M, Sofiabadi M. Effect of Royal Jelly on Blood Glucose and Lipids in Streptozotocin Induced Type 1 Diabetic Rats. J Arak Uni Med Sci 2017;20(5):48-56. 28. Yeylaghi Ashrafi M R, Abednatanzi H , Ghazalian F. The effect of eight weeks of high intensity interval training and n-chromosomal royal jelly on G6Pase gene expression in hepatocytes, glucose levels and insulin resistance in type 2 diabetic rats. RJMS 2021;27(10):135-50. 29. Kocot J, Kiełczykowska M, Luchowska-Kocot D, Kurzepa J, Musik I. Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application. Oxid Med Cell Longev. 2018 May 2;2018:7074209. doi: 10.1155/2018/7074209. PMID: 29854089; PMCID: PMC5954854..30. Rauter AP, Martins A, Borges C, Mota-Filipe H, Pinto R, Sepodes B, Justino J. Antihyperglycemics and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res. 2010 Jun;24 Suppl 2:S133-8. doi: 10.1002/ptr.3017. Erratum in: Phytother Res. 2010 Jun;24 Suppl 2:S233-4. PMID: 20309949..31. Amirshahi T, Nejati V, Najafi G. Biochemical and Histological Evaluation of Protective Effect of Royal Jelly on PancreasInduced Oxidative Stress in Male Rat Pancreas. J MazandaranUniv Med Sci 2013;23(107):107-15. [in Persian].32. Xiang X, Liu Y, Zhang X, Zhang W, Wang Z. [Effects of biotin on blood glucose regulation in type 2 diabetes rat model]. Wei Sheng Yan Jiu. 2015 Mar;44(2):185-9, 195. Chinese. PMID: 25997216.33. Samiee RF, Ziaee A, Qambarian A, Mirmiran P, Momenan A, Azizi F. Association between risk factors of cardiovascular diseases and obesity among Tehranian women: Tehran Lipid and Glucose Study (TLGS). Iran J Endocrinol Metab 2012; 14(2):101-8.EbrahimFallahPegahHooshangiMohammad Jahangiri122023233510.52547/jspac.40182.3.7.23http://jspac.etb.iau.ir/en/Article/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/40182http://jspac.etb.iau.ir/en/Article/Download/401821. Serrano J, Shahidian S, Sampaio J, Leite N. The importance of sports performance factors and training contents from the perspective of futsal coaches. J Hum Kinet. 2013 Oct 8; 38:151-60. doi: 10.2478/hukin-2013-0055. PMID: 24235991; PMCID: PMC3827762. 2. Amiri-Khorasani M, Mohammadkazemi R, Sarafrazi S, Riyahi-Malayeri S, Sotoodeh V. Kinematics analyses related to stretch-shortening cycle during soccer instep kicking after different acute stretching. J Strength Cond Res. 2012 Nov;26(11):3010-7. doi: 10.1519/JSC.0b013e3182443442. PMID: 22158101.3. Shirvani, H., Riyahi malayeri, S., Akbarpour Bani, M., Kazemzadeh, Y. (2013). 'The Effects of Taurine Supplementation with High Intensity Intermittent Exercise on Serum IL-6 and TNF-α in Well-Trained Soccer Players', Journal of Sport Biosciences, 5(2), pp. 59-79. doi: 10.22059/jsb.2013.350404. Chmura P, Podgórski T, Konefał M, Rokita A, Chmura J, Andrzejewski M. Endocrine Responses to Various 1 × 1 Small-Sided Games in Youth Soccer Players. Int J Environ Res Public Health. 2019 Dec 6;16(24):4974. doi: 10.3390/ijerph16244974. PMID: 31817816; PMCID: PMC6950523.5. Bellinger P. Functional Overreaching in Endurance Athletes: A Necessity or Cause for Concern? Sports Med. 2020 Jun;50(6):1059-1073. doi: 10.1007/s40279-020-01269-w. PMID: 32064575.6. Handziski Z, Maleska V, Petrovska S, Nikolik S, Mickoska E, Dalip M, Kostova E. The changes of ACTH, cortisol, testosterone and testosterone/cortisol ratio in professional soccer players during a competition half-season. Bratisl Lek Listy. 2006;107(6-7):259-63. PMID: 17051905.7. Manchado M, Sampaio-Jorge F, Dias N, Knifis FW. Effect of oral creatine supplementation in soccer players metabolism. Int J of Sport Sci. 2008; 10(4): 44-58. doi: 10.5232/ricyde.8. Ghoochani S, Riyahi Malayeri S, Daneshjo A. Short-term effect of Citrulline Malate supplement on LDH and Lactate levels and Resistance Exercise Performance. J Mil Med 2020; 22 (S1): 154-162.URL: http://militarymedj.ir/article-1-2669-en.html.9. Stølen T, Chamari K, Castagna C, Wisløff U. Physiology of soccer: an update. Sports Med. 2005;35(6):501-36. doi: 10.2165/00007256-200535060-00004. PMID: 15974635. 10. Mujika I, Goya A, Padilla S, Grijalba A, Gorostiaga E, Ibañez J. Physiological responses to a 6-d taper in middle-distance runners: influence of training intensity and volume. Med Sci Sports Exerc. 2000 Feb;32(2):511-7. doi: 10.1097/00005768-200002000-00038. PMID: 10694140.11. Mujika I, Goya A, Ruiz E, Grijalba A, Santisteban J, Padilla S. Physiological and performance responses to a 6-day taper in middle-distance runners: influence of training frequency. Int J Sports Med. 2002 Jul;23(5):367-73. doi: 10.1055/s-2002-33146. PMID: 12165889.12. Stølen T, Chamari K, Castagna C, Wisløff U. Physiology of soccer: an update. Sports Med. 2005;35(6):501-36. doi: 10.2165/00007256-200535060-00004. PMID: 15974635. 13. Riyahi Malayeri, Shahin, Mousavi Sadati, Seyed Kazem, Effect of beta-alanine supplementation on carnosine amount and muscle strength of the upper and lower extremities of bodybuilding athletes. Journal of Sports Physiology and Athletic Conditioning, 2021;1(1):11-20. doi: 10.52547/jspac.19831.1.1.1114. Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients. 2021 Jun 2;13(6):1915. doi: 10.3390/nu13061915. PMID: 34199588; PMCID: PMC8228369.15. Stølen T, Chamari K, Castagna C, Wisløff U. Physiology of soccer: an update. Sports Med. 2005;35(6):501-36. doi: 10.2165/00007256-200535060-00004. PMID: 15974635.16. Butts J, Jacobs B, Silvis M. Creatine Use in Sports. Sports Health. 2018 Jan/Feb;10(1):31-34. doi: 10.1177/1941738117737248. Epub 2017 Oct 23. PMID: 29059531; PMCID: PMC5753968.17. Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients. 2021 Jun 2;13(6):1915. doi: 10.3390/nu13061915. PMID: 34199588; PMCID: PMC8228369. 23. 18. Volek JS, Ratamess NA, Rubin MR, Gómez AL, French DN, McGuigan MM, Scheett TP, Sharman MJ, Häkkinen K, Kraemer WJ. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol. 2004 May;91(5-6):628-37. doi: 10.1007/s00421-003-1031-z. Epub 2003 Dec 18. PMID: 14685870.19. Mujika I. The influence of training characteristics and tapering on the adaptation in highly trained individuals: a review. Int J Sports Med. 1998 Oct;19(7):439-46. doi: 10.1055/s-2007-971942. PMID: 9839839.20. Steinacker JM, Lormes W, Kellmann M, Liu Y, Reissnecker S, Opitz-Gress A, Baller B, Günther K, Petersen KG, Kallus KW, Lehmann M, Altenburg D. Training of junior rowers before world championships. Effects on performance, mood state and selected hormonal and metabolic responses. J Sports Med Phys Fitness. 2000 Dec;40(4):327-35. PMID: 11297003.21. Costill DL, Thomas R, Robergs RA, Pascoe D, Lambert C, Barr S, Fink WJ. Adaptations to swimming training: influence of training volume. Med Sci Sports Exerc. 1991 Mar;23(3):371-7. PMID: 2020277.22. Dressendorfer RH, Petersen SR, Moss Lovshin SE, Hannon JL, Lee SF, Bell GJ. Performance enhancement with maintenance of resting immune status after intensified cycle training. Clin J Sport Med. 2002 Sep;12(5):301-7. doi: 10.1097/00042752-200209000-00008. PMID: 12394203.23. Hoffman JR, Stout JR, Falvo MJ, Kang J, Ratamess NA. Effect of low-dose, short-duration creatine supplementation on anaerobic exercise performance. J Strength Cond Res. 2005 May;19(2):260-4. doi: 10.1519/15484.1. PMID: 1590335924. Lac G, Berthon P. Changes in cortisol and testosterone levels and T/C ratio during an endurance competition and recovery. J Sports Med Phys Fitness. 2000 Jun;40(2):139-44. PMID: 11034434. 25. Martínez AC, Seco Calvo J, Tur Marí JA, Abecia Inchaurregui LC, Orella EE, Biescas AP. Testosterone and cortisol changes in professional basketball players through a season competition. J Strength Cond Res. 2010 Apr;24(4):1102-8. doi: 10.1519/JSC.0b013e3181ce2423. PMID: 20375720. MaryamTakhtyFarshad GhazalianShahram Soheilikhosrow Ebrahim122023506210.52547/jspac.40308.3.7.50http://jspac.etb.iau.ir/en/Article/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/40308http://jspac.etb.iau.ir/en/Article/Download/403081. Sarma S, Sockalingam S, Dash S. Obesity as a multisystem disease: Trends in obesity rates and obesity-related complications. Diabetes Obes Metab. 2021 Feb;23 Suppl 1:3-16. doi: 10.1111/dom.14290. PMID: 33621415.2. WHO. Obesity and overweight. World Health Organization. 2021.3. Farazandeh Nia, D., Hosseini, M., Riyahi Malayeri, S., Daneshjoo, A. Effect of Eight Weeks of Swimming Training with Garlic Intake on Serum Levels of IL-10 and TNF-α in Obese Male Rats. Jundishapur Scientific Medical Journal, 2018; 16(6): 665-671. doi: 10.22118/jsmj.2018.57830.4. Haghighi AH, Yaghoubi M. The effect of eight weeks aerobic training and green tea supplementation on body fat percentage and serum lipid profiles in obese and overweight women. Medical journal of mashhad university of medical sciences. 2013;56(4):211-8.5. Riyahi Malayeri S, Mirakhorli M. The Effect of 8 Weeks of Moderate Intensity Interval Training on Omentin Levels and Insulin Resistance Index in Obese Adolescent Girls. Sport Physiology & Management Investigations. 2018;10(2):59-68. http://www.sportrc.ir/article_67070.html?lang=en.6. Riyahi Malayeri S, Saei M. Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese men. Sport Physiology & Management Investigations. 2019;10(4):31-42. http://www.sportrc.ir/article_82662.html?lang=en.7. Hosseini M, Naderi S, Mousavi-Sadati, S K, Riyahi S. Effect of High Intensity Interval Training on the Level of Leptin and Liver Enzymes in Obese and Overweight Males. sjimu 2019; 27 (2) :41-50. doi: 10.29252/sjimu.27.2.418. Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Med. 2014 Feb;44(2):211-21. doi: 10.1007/s40279-013-0110-5. PMID: 24174305; PMCID: PMC3906547.9. Ong KW, Hsu A, Tan BK. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol. 2013 May 1;85(9):1341-51. doi: 10.1016/j.bcp.2013.02.008. Epub 2013 Feb 14. PMID: 23416115.10. Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract. 2011;2011:382852. doi: 10.1155/2011/382852. Epub 2010 Aug 31. PMID: 20871849; PMCID: PMC2943088..11. Ong KW, Hsu A, Tan BK. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol. 2013 May 1;85(9):1341-51. doi: 10.1016/j.bcp.2013.02.008. Epub 2013 Feb 14. PMID: 23416115.12. Yau WW, Yen PM. Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. Int J Mol Sci. 2020 Apr 24;21(8):3020. doi: 10.3390/ijms21083020. PMID: 32344721; PMCID: PMC7215895.13. Gaudry MJ, Keuper M, Jastroch M. Molecular evolution of thermogenic uncoupling protein 1 and implications for medical intervention of human disease. Mol Aspects Med. 2019 Aug;68:6-17. doi: 10.1016/j.mam.2019.06.006. Epub 2019 Jul 18. PMID: 31238069.14. Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: a randomised clinical trial. Br J Nutr. 2018 Feb;119(3):250-258. doi: 10.1017/S0007114517003439. Epub 2018 Jan 8. PMID: 29307310.15. Daneshyar S, OmidAli F, Feizipour S A. THE COMBINED EFFECT OF LONG-TERM FEEDING OF HIGH-FAT DIET AND REGULAR AEROBIC TRAINING ON GENE EXPRESSION OF UNCOUPLING PROTEIN 1 (UCP1) IN BROWN ADIPOSE TISSUE AND SARCOLIPIN (SLN) IN SOLEUS MUSCLE OF MICE: AN EXPERIMENTAL STUDY. Studies in Medical Sciences 2021; 32 (4) :290-302URL: http://umj.umsu.ac.ir/article-1-5341-en.html16. Xu X, Ying Z, Cai M, Xu Z, Li Y, Jiang SY, Tzan K, Wang A, Parthasarathy S, He G, Rajagopalan S, Sun Q. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1115-25. doi: 10.1152/ajpregu.00806.2010. Epub 2011 Mar 2. PMID: 21368268; PMCID: PMC3094041.17. Daneshyar S, Kordi MR, Gaeini A, Kadivar M, Afshari S. The effect of endurance training on gene expression of Uncoupling Protein 1 (UCP-1) in white visceral adipose tissue of retroperitoneal depot of male Wistar rats. Razi Journal of Medical Sciences. 2015;22(136):35-45.18. Shirkhani S, Marandi SM, Kazeminasab F, Esmaeili M, Ghaedi K, Esfarjani F, Shiralian-Esfahani H, Nasr-Esfahani MH. Comparative studies on the effects of high-fat diet, endurance training and obesity on Ucp1 expression in male C57BL/6 mice. Gene. 2018 Nov 15;676:16-21. doi: 10.1016/j.gene.2018.07.015. Epub 2018 Jul 6. PMID: 30201103.19. Deng H, Zhang W, Ruan D, Chen D, Xu X, He X, et al. The Combination of Aerobic and Resistance Exercise Induces Weight Loss via the PGC-1α/Irisin/UCP-1 Pathway. Journal of Biomaterials and Tissue Engineering. 2019;9(10):1388-94.20. Flouris AD, Dinas PC, Valente A, Andrade CMB, Kawashita NH, Sakellariou P. Exercise-induced effects on UCP1 expression in classical brown adipose tissue: a systematic review. Horm Mol Biol Clin Investig. 2017 Jan 13;31(2):/j/hmbci.2017.31.issue-2/hmbci-2016-0048/hmbci-2016-0048.xml. doi: 10.1515/hmbci-2016-0048. PMID: 28085671.21. Ye X, Li J, Gao Z, Wang D, Wang H, Wu J. Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway. Biomed Res Int. 2022 Feb 25;2022:4919153. doi: 10.1155/2022/4919153. PMID: 35257010; PMCID: PMC8897747.22. Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Mol Cell. 2019 May 16;74(4):844-857.e7. doi: 10.1016/j.molcel.2019.03.021. Epub 2019 Apr 15. PMID: 31000437; PMCID: PMC6525068.23. Huang K, Liang XC, Zhong YL, He WY, Wang Z. 5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription. J Sci Food Agric. 2015 Jul;95(9):1903-10. doi: 10.1002/jsfa.6896. Epub 2014 Oct 1. PMID: 25186103.24. Sudhakar M, Sasikumar SJ, Silambanan S, Natarajan D, Ramakrishnan R, Nair AJ, et al. Chlorogenic acid promotes development of brown adipocyte-like phenotype in 3T3-L1 adipocytes. Journal of Functional Foods. 2020;74:104161.Abdolhamid Mosalla nezhad Farzaneh Taghian Khosrow Jalali DehkordiSeyed Ali Hosseini 122023768310.52547/jspac.40619.3.7.76http://jspac.etb.iau.ir/en/Article/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/40619http://jspac.etb.iau.ir/en/Article/Download/406191. Vigne S, Duc D, Peter B, Rebeaud J, Yersin Y, Ruiz F, Bressoud V, Collet TH, Pot C. Lowering blood cholesterol does not affect neuroinflammation in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2022 Feb 7;19(1):42. doi: 10.1186/s12974-022-02409-x. PMID: 35130916; PMCID: PMC8822860.2. Wu R, Su Y, Yuan Q, Li L, Wuri J, Liu X, Yan T. Sex Effect on Cardiac Damage in Mice With Experimental Autoimmune Encephalomyelitis. ASN Neuro. 2021 Jan-Dec; 13:1759091421991771. doi: 10.1177/1759091421991771. PMID: 33541127; PMCID: PMC7868497. 3. Scanzano A, Cosentino M. Adrenergic regulation of innate immunity: a review. Front Pharmacol. 2015 Aug 13;6:171. doi: 10.3389/fphar.2015.00171. PMID: 26321956; PMCID: PMC4534859. 4. Bellocchi C, Carandina A, Montinaro B, Targetti E, Furlan L, Rodrigues GD, Tobaldini E, Montano N. The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int J Mol Sci. 2022 Feb 23;23(5):2449. doi: 10.3390/ijms23052449. PMID: 35269591; PMCID: PMC8910153.5. Kaplan TB, Berkowitz AL, Samuels MA. Cardiovascular Dysfunction in Multiple Sclerosis. Neurologist. 2015 Dec;20(6):108-14. doi: 10.1097/NRL.0000000000000064. PMID: 26671744.6. Fahim M, Rafiee Zadeh A, Shoureshi P, Ghadimi K, Cheshmavar M, Sheikhinia N, Afzali M. Alcohol and multiple sclerosis: an immune system-based review. Int J Physiol Pathophysiol Pharmacol. 2020 Apr 15;12(2):58-69. PMID: 32419901; PMCID: PMC7218739. 7. Robinson AP, Harp CT, Noronha A, Miller SD. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol. 2014;122:173-89. doi: 10.1016/B978-0-444-52001-2.00008-X. PMID: 24507518; PMCID: PMC3981554. 8. Einstein O, Fainstein N, Touloumi O, Lagoudaki R, Hanya E, Grigoriadis N, Katz A, Ben-Hur T. Exercise training attenuates experimental autoimmune encephalomyelitis by peripheral immunomodulation rather than direct neuroprotection. Exp Neurol. 2018 Jan;299(Pt A):56-64. doi: 10.1016/j.expneurol.2017.10.008. Epub 2017 Oct 12. PMID: 29031957.10. Agahi MRH, Mosallanejad Z, Salehi OR. The effects of resistance training and spirulina on the performance of the antioxidant system with emphasis on mir125b, mir146a and cognitive function in stanazolol-induced neurotoxicity in rats. Chem Biol Interact. 2022;110112. 11. Ali AM, Kunugi H. Royal Jelly as an Intelligent Anti-Aging Agent-A Focus on Cognitive Aging and Alzheimer's Disease: A Review. Antioxidants (Basel). 2020 Sep 29;9(10):937. doi: 10.3390/antiox9100937. PMID: 33003559; PMCID: PMC7601550. 12. Petelin A, Kenig S, Kopinč R, Deželak M, Černelič Bizjak M, Jenko Pražnikar Z. Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults. Evid Based Complement Alternat Med. 2019 Jun 13;2019:4969720. doi: 10.1155/2019/4969720. PMID: 31312222; PMCID: PMC6595335. 13. Mousavi S, Fallahmohammadi Z, Hajizadeh Moghaddam A. Evaluating the protective effect of 6 weeks resistance training and vitamin D intake on brain neuro-inflammatory factors in female rats with experimental autoimmune encephalomyelitis . Feyz 2018; 22 (6) :573-580URL: http://feyz.kaums.ac.ir/article-1-3658-en.html. 14. Abedi E, Khezri S, Abtahi S M. Evaluation of the chlorpromazine effect on experimental autoimmune encephalomyelitis in male rats. J Shahrekord Univ Med Sci. 2017; 18 (6) :91-101URL: http://78.39.35.44/article-1-2711-en.html. 15. Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I. Exercise exerts neuroprotective effects on Parkinson's disease model of rats. Brain Res. 2010 Jan 15;1310:200-7. doi: 10.1016/j.brainres.2009.10.075. Epub 2009 Nov 10. PMID: 19900418. 16. Bernardes D, Oliveira ALR de. Regular exercise modifies histopathological outcomes of pharmacological treatment in experimental autoimmune encephalomyelitis. Front Neurol. 2018;9:950. 17. Malekinejad H, Ahsan S, Delkhosh-Kasmaie F, Cheraghi H, Rezaei-Golmisheh A, Janbaz-Acyabar H. Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats. Iran J Basic Med Sci. 2016 Feb;19(2):221-7. PMID: 27081469; PMCID: PMC4818372. 18. Hosseini SA, Hamzavi K, Safarzadeh H, Salehi O. Interactive effect of swimming training and fenugreek (Trigonella foenum graecum L.) extract on glycemic indices and lipid profile in diabetic rats. Arch Physiol Biochem. 2020 Oct 5:1-5. doi: 10.1080/13813455.2020.1826529. Epub ahead of print. PMID: 33017260. 19. Jastrzebski D, Toczylowska B, Zieminska E, Zebrowska A, Kostorz-Nosal S, Swietochowska E, Di Giulio C, Ziora D. The effects of exercise training on lipid profile in patients with sarcoidosis. Sci Rep. 2021 Mar 10;11(1):5551. doi: 10.1038/s41598-021-84815-4. PMID: 33692469; PMCID: PMC7946908. 20. Monazamnezhad A, Habibi A, Majdinasab N, Ghalvand A. The effects of aerobic exercise on lipid profile and body composition in women with multiple sclerosis. Jundishapur J Chronic Dis Care. 2015;4(1). 21. Jalali Dehkordi K, Hosseini SA. The Effect of Aerobic Training with Royal Jelly Consumption on Health Related Anthropometric Markers in an Experimental Autoimmune Encephalomyelitis Model. Jorjani Biomed J. 2021;9(4):1–12. 22. Jorissen W, Vanmierlo T, Wens I, Somers V, Van Wijmeersch B, Bogie JF, Remaley AT, Eijnde BO, Hendriks JJA. Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients. Int J Mol Sci. 2018 Jan 8;19(1):193. doi: 10.3390/ijms19010193. PMID: 29316715; PMCID: PMC5796142.23. Mobasseri M, Pourmoradian S, Mahdavi R, Faramarzi E. Effects of royal jelly supplementation on lipid profile and high-sensitivity c-reactive protein levels in type-2 diabetic women: A pilot study. Curr Top Nutraceutical Res. 2014;12(3).