مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 6 20 2026 9 14 Thermogenesis of brown fat adipose tissue in response to aerobic exercise Thermogenesis of brown fat adipose tissue in response to aerobic exercise en Sarvenaz Aliasgari Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Mohammad Ali Azarbayjani sirvan Atashak Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran maghsoud peeri Central Tehran Branch, Islamic Azad University, Tehran, Iran Saleh Rahmati Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran 2026 6 19 <p>Due to decreased physical activity and excessive energy intake, obesity and its related metabolic diseases have become increasingly prevalent worldwide. Aerobic exercise is recognized as an effective non-pharmacological strategy for obesity management, acting through multiple mechanisms, including increased energy expenditure, improved substrate utilization, and regulation of body composition. One proposed mechanism is the activation of brown adipose tissue thermogenesis. Brown adipose tissue is rich in mitochondria and expresses uncoupling protein 1 (UCP1), which enables the oxidation of glucose and fatty acids to generate heat rather than adenosine triphosphate. Through this process, BAT can contribute to daily energy expenditure and may help prevent excessive fat accumulation. Cold exposure, regular physical activity, and certain phytochemical compounds have been reported to activate thermogenic signaling pathways and enhance energy metabolism, partly through sympathetic stimulation and beta-3 adrenergic receptor activation in BAT. Although animal studies, particularly in rodent models, have suggested that aerobic exercise may stimulate brown fat thermogenesis and browning of white adipose tissue, evidence in humans remains limited and inconsistent. Some studies have reported beneficial effects, whereas others have failed to confirm a significant change in BAT activity after exercise training. Therefore, the thermogenic role of aerobic exercise in humans remains uncertain. Further well-designed clinical studies are needed to clarify whether exercise-induced activation of brown adipose tissue contributes meaningfully to obesity prevention and metabolic health.</p> http://jspac.etb.iau.ir/fa/Article/Download/53867