مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Sports Physiology and Athletic Conditioning 2783-3038 6 20 2026 9 14 The effect of aerobic exercise combined with gallic acid on SOD and GPx in kidney tissue of rats exposed to cadmium. The effect of aerobic exercise combined with gallic acid on SOD and GPx in kidney tissue of rats exposed to cadmium. en Meysam Zayerchi Seyed Ali Hosseini Department of Sport Physiology, Marv.C, Islamic Azad University, Marvdasht, Iran Mohammad Ali Azarbayjani Department of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran Heshmatollah Parsian Department of Physical Education and Sport Science, ShQ.C., Islamic Azad University, Shahr-e Qods, Iran Rouhallah Ershadi Department of Physical Education and sport science, Bu.C., Islamic Azad University, Bushehr, Iran 2025 12 15 Introduction: Environmental pollution, including cadmium, is associated with impaired organ function, including the kidneys. On the other hand, although the effect of exercise and some natural antioxidants on improving kidney function has been shown, the present study aimed to investigate the effect of aerobic exercise combined with gallic acid on SOD and GPx in kidney tissue of rats exposed to cadmium. Methods: In this experimental study, 42 male Sprague-Dawley rats, 8- 10 weeks old and weighing 200- 250 g, were randomly divided into 6 groups including 1) healthy control, 2) sham (only receiving gallic acid solution), 3) cadmium, 4) cadmium + gallic acid, 5) cadmium + exercise, and 6) cadmium + gallic acid + exercise. Rats in the cadmium groups consumed 5 mg/kg of cadmium dissolved in drinking water daily. The exercise groups ran for 30-60 minutes at a speed of 15 m/min and a 15-degree incline for eight weeks and five sessions per week. Also, 20 mg/kg of gallic acid was orally administered daily in food flavoring to rats. For data analysis, one-way ANOVA with Tukey post- hoc test and two-way ANOVA tests were used. The findings of the present study were analyzed in SPSS version 22 software with a significance level of 0.05. Results: The results showed that in the cadmium group, the levels of SOD and GPx were significantly lower than healthy control group (P=0.001). In the exercise and gallic acid groups, the levels of SOD and GPx were significantly higher than control group (P≤0.05). Also, exercise and gallic acid have an interactive effect on increasing SOD in the kidney tissue of rats exposed to cadmium (P≤0.05). Conclusion: It seems that aerobic exercise and gallic acid can probably enhance each other's effect in improving some antioxidant markers through common pathways.

http://jspac.etb.iau.ir/fa/Article/Download/52479